Tag: M.W:200-300

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 89891-65-6. In a patent£¬Which mentioned a new discovery about 89891-65-6, molcular formula is C8H4BrClN2, introducing its new discovery.

THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS

Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 89891-65-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 89891-65-6

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1971 | ChemSpider

148231-12-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.148231-12-3, Name is 5,8-Dibromoquinoxaline, molecular formula is C8H4Br2N2. In a article£¬once mentioned of 148231-12-3

Bromination of quinoxaline and derivatives: Effective synthesis of some new brominated quinoxalines

The synthesis of brominated quinoxaline derivatives starting from several kinds of quinoxaline by different bromination strategies was studied. First the synthesis of some brominated quinoxalines was accomplished along with the development of an alternative and effective synthesis of some known compounds. A new, clean, and effective synthetic method for selective reduction of quinoxaline to 1,2,3,4-tetrahydroquinoxaline was also developed. The products obtained were characterized by means of NMR spectroscopy, elemental analyses, and mass spectrometry.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 148231-12-3, In my other articles, you can also check out more blogs about 148231-12-3

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2047 | ChemSpider

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 108229-82-9, In a patent£¬Which mentioned a new discovery about 108229-82-9

Pyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxalines and pyrrolo[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxalines

This disclosure describes substituted 2,3,3a,4-tetrahydro-1H-pyrrolo[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxalines and 1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxalines which possess anxioyltic activity.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1994 | ChemSpider

25983-13-5, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 25983-13-5

A method for preparing cephalosporin lorraine ester intermediate (by machine translation)

The invention provides a method for preparing cephalosporin lorraine ester intermediate, comprises the following steps: in a free radical initiator under the catalysis, 3 – chlorine spore with 4 – (4 – pyridyl) – 2 – mercapto thiazole generate condensation reaction, the recurrence of quaternization reaction, to obtain the pyridine salt; then for the protection of the skin of a pot, to obtain cephalosporin lorraine ester intermediate. Compared with the prior art, the present invention relates to 3 – chlorine spore as the initial reactant, for the first application; 3 – chlorine spore with 4 – (4 – pyridyl) – 2 – mercapto thiazole condensation reaction by free radical initiator catalytic, and is safe, convenient processing, which belongs to the environment-friendly reaction type, at the same time the reaction is greatly reduced and the generation of the isomer; using the one-pot synthesis at the same time get rid of 4 bits and the 7 position of the protecting group, thereby greatly simplifying the reaction process, and improves the reaction yield and the quality of the product. The synthesis method simple technology, without harsh reaction conditions and the like, is extremely suitable for industrial production. (by machine translation)

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1839 | ChemSpider

148231-12-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.148231-12-3, Name is 5,8-Dibromoquinoxaline, molecular formula is C8H4Br2N2. In a Article, authors is Sakurai, Hidehiro£¬once mentioned of 148231-12-3

Synthesis and characterization of p-phenylenediamine derivatives bearing an electron-acceptor unit

(Chemical Equation Presented) Two series of aniline oligomers bearing fused heterocycles as an electron-acceptor unit were synthesized. They consist of aniline or its derivatives as an electron donor and benzothiadiazole (BT) or quinoxaline (QX) as an electron-acceptor unit. Benzothiadiazoles 1-3 were synthesized by palladium-catalyzed amination. Quinoxalines 4-6 were prepared by palladium-catalyzed amination or transformation from the benzothiadiazoles. These compounds showed a HOMO-LUMO gap smaller than those of their analogues such as thiophene-substituted BT/QXs. Cyclic voltammetry revealed that the electrochemical behavior is dependent on the position of the acceptor heterocycle. Chemical oxidation with Ag2O afforded the corresponding 1,4-quinonediimine derivatives as an E,E-isomer, stereoselectively. As for the BT pentamer analogues 2 and 3, the first oxidation selectively occurred at the amino group adjacent to the benzothiadiazole unit, giving the regiospecific half-oxidized derivatives. Furthermore, the fully oxidized derivative 24 was isolated and characterized.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 148231-12-3

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2042 | ChemSpider

7712-28-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 7712-28-9, C11H10N2O3. A document type is Article, introducing its new discovery.

Synthesis of potential chemotherapic quinoxalinone derivatives by biocatalysis or microwave-assisted Hinsberg reaction

In recent years, great efforts have been dedicated to the design of compounds acting as selective inhibitors of the HIV-1 reverse transcriptase (RT). Due to the promissory results previously attained with some quinoxaline derivatives, we aimed to improve the specific standard Hinsberg synthetic pathway by means of biocatalysis or microwave (MW) irradiation. Both techniques rendered the products in very good yields. However, employing the microwave-assisted organic synthesis (MAOS), in the absence of solvent, the same reactions may be completed in minutes. Some of these quinoxalinone derivatives exhibited good inhibitor activity against some human tumoral cells and the lymphoma related to HIV-1.

Interested yet? Keep reading other articles of 1271-51-8!, 7712-28-9

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1749 | ChemSpider

50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50998-17-9, To a flask including 1 eq. of triphenylen-2-ylboronic acid and 1.2 eq. of 6-bromoquinoxaline, 0.03 eq. of Pd(dba)3, 0.06 eq. of (t-Bu)3P, and toluene (1 M) were added and refluxed with stirring for about 12 hours. Then, the reaction product was cooled to ambient temperature, extracted with methylene chloride and washed with distilled water. The product thus obtained was dried with MgSO4 and distilled under a reduced pressure, and the residue was separated by column chromatography to produce Compound B-1 (Yield 80.4%). The compound thus produced was identified using a high resolution mass spectrometer and 1H NMR. The mass of the synthesized compound thus identified was 355. [HRMS for C26H16N2 [M]+: calcd: 356.43, found: 355, Elemental Analysis for C26H16N2 calcd: C, 87.62; H, 4.52; N, 7.86].

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; SAMSUNG DISPLAY CO., LTD.; JEONG, Hyein; LEE, Jungsub; (58 pag.)US2017/162796; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, To a stirred solution of compound 1A (0.2 g, 0.79 mmol) and 2-methoxy-6-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine lB (0. 24 g, 1.02 mmol) in 1,4-dioxane (10 mL)/H20 (2 mL) was added K3P04 (0.5 g, 2.36 mmol). The reaction mixture was degassed for 3 mm. and then to it was added the PdC12(dppf)-CH2C12 adduct (0.032 g, 0.03 9 mmol), and the resultant mixture was heated at 100 C for 12 h. The reaction mixture was then filtered through a Celite pad, the filter cake washed with ethyl acetate and the combined filtrate evaporated under reduced pressure to give the cmde compound, which was purified by preparative HPLC (condition N) to yield 6-(6?-methoxy-[2,2?-bipyridinj -3-yl)imidazo [1,2- ajpyridine-3-carbonitrile 17 (0.2 mg, 0.054 mmol, 68.5 % yield). Compound 20B was synthesized by reacting 20A and 2-chloro-3-(4,4,5,5-tetramethyl- 1,3,2-dioxaborolan-2-yl)pyridine (reference: WO 2015157093 Al, WO 2015044172 Al and WO 2014055955 Al) employing the experimental procedure described in Scheme-5 (Method E). The cmde product was purified by silica gel chromatography (40 g RediSep column, eluting with 50 % ethyl acetate in petroleum ether) to yield compound 20B (2.32 g, 9.610 . +mmol, 67.0 /o yield) as alight yellow solid. LCMS: m/z = 242.0 [M+Hj ; ret. time 1.66 mm; condition C.

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; DING, Pingyu; GELMAN, Marina; KINSELLA, Todd; SINGH, Rajinder; BHAMIDIPATI, Somasekhar; VELAPARTHI, Upender; BORZILLERI, Robert, M.; RAHAMAN, Hasibur; WARRIER, Jayakumar, Sankara; (232 pag.)WO2016/133838; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. Preparation of compound 2a A 25-mL round bottom flask equipped with a magnetic stirrer, a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline (100 mg, 0.48 mmol), 4- Fluorophenylboronic acid (80 mg, 0.57 mmol), water/dioxane (1.0 mL/4.0 ml), K2C03 (132 mg, 0.96 mmol). The resulting solution was degassed for 15 min, then Pd(PPh3)4 (27 mg, 0.024 mmol) was added. The reaction mixture was warmed to 100 C and stirred for 1 h. After cooled to room temperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHC03, brine, dried over Na2S04. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with EtOAc hexanes solvent system afforded the desired compound (40 mg, 38% yield). NMR (400 MHz, CDC13) delta 9.34 (s, 1H), 8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25 (m, 1H).

36856-91-4, The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond, J.; PARHI, Ajit; PILCH, Daniel, S.; KAUL, Malvika; WO2013/106756; (2013); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,49679-45-0

General procedure: Method A: a solution of compound 3 (1.11 g, 4.70 mmol), 3- aminophenol (622 mg, 5.70 mmol) and p-TSA, as a catalyst, in absolute ethanol (40 mL) was refluxed for 110 h. Ethanol was then evaporated under reduced pressure, and the resulting residue was purified by silica column chromatography using cyclohexane with ethyl acetate gradient (0e50%) as eluent to give the desired compound 4a (1.0 g, 69%) as a red powder.

As the paragraph descriping shows that 49679-45-0 is playing an increasingly important role.

Reference£º
Article; Oyallon, Bruno; Brachet-Botineau, Marie; Loge, Cedric; Bonnet, Pascal; Souab, Mohamed; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Berthelot, Pascal; Gouilleux, Fabrice; Viaud-Massuard, Marie-Claude; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 101 – 109;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider