Tag: M.W:200-300

2958-87-4, 2,3,6-Trichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 20 By reaction of 2,3,6-trichloroquinoxaline with propargylamine, following a procedure that is similar to that described in example 2, there is obtained 8-chloro-1-methylimidazo[1,2-a]quinoxaline-4(5H)-one (m.p. >300 C.) and, subsequently, 4,8-dichloro-1-methylimidazo[1,2-a] quinoxaline., 2958-87-4

2958-87-4 2,3,6-Trichloroquinoxaline 18070, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Biomedica Foscama Industria Chimicofarmaceutica S.p.A.; US6124287; (2000); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2).

49679-45-0, 49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

In N2in the gas purification system, the carbazole is dissolved in 1,4-dioxane solvent, and by adding CuI and K3PO4. Add another 5,8- […][…] (1.1 equivalent) and trans -1,2-diamino cyclohexane. In the solution 110 C and the temperature of the refluxing under stirring 24 hours. After the completion of reaction, to the room temperature and cooling the solution and distilled water extraction by ethyl acetate. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the remaining organic solvent. The material through the use of hexane and ethyl acetate to carry out wet refining column chromatography, thereby obtaining compound “l”. (Yield: 48%)

148231-12-3, The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 15 2-[(Propylamino)(propylimino)methylthio]-3-quinoxalinecarboxylic acid ethyl ester, hydrochloride 2-Chloro-3-quinoxalinecarboxylic acid ethyl ester (3.551 g., 0.015 mole) and 2.405 g. (0.015 mole) of 1,3-di-n-propylthiourea were dissolved in acetone and heated at reflux for 11/2 hours. The solution was concentrated to a volume of 50 ml. and cooled. A small amount of solid was removed by filtration. The filtrate was further concentrated to a volume of 25 ml. and ether was added to turbidity. After the reaction mixture had been cooled the yellow solid was collected by filtration to give 2.77 g. (46.6%) of the product, m.p. 129-130 C. Analysis for: C18 H25 ClN4 O2 S Calculated: C, 54.47; H, 6.35; N, 14.12; Cl, 8.93; S, 8.08. Found: C, 54.42; H, 6.50; N, 14.12; Cl, 8.87; S, 8.07., 49679-45-0

49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of tert-butyl (2S)-2-[5-(2-chloropyrimidin-5-yl)-1 H-imidazol-2-yl]pyrrolidine-1-carboxylate (0.11 g, 0.33 mmol), obtained from Preparation 101 , in dry dioxane (2 mL), was added hexamethylditin (0.11 g, 0.33 mmol), followed by Pd(PPh3)4 (0.095 g, 0.082 mmol). The reaction mixture was degassed and then heated to reflux for 2 hours. After this time, it was cooled to room temperature and diluted with ethyl acetate (20 ml_). The organic phase was washed with saturated ammonium chloride solution (20 ml_), water (20 ml_) and brine (20 ml_); then dried over anhydrous sodium sulphate, filtered and the solvent was removed in vacuo. The residue was dissolved in DMF (2 ml_) and 6-bromo-2-chloroquinoxaline (0.088 g, 0.33 mmol), obtained from Preparation 30, was added, followed by cesium fluoride (0.09 g, 0.59 mmol), copper (I) chloride (0.033 g, 0.33 mmol) and Pd(PPh3)4 (0.095 g, 0.082 mmol). The reaction mixture was degassed and stirred at 1100C for 3.5 hours. It was then allowed to cool to room temperature and was diluted with ethyl acetate (20 ml_). The resulting suspension was washed with 0.88 ammonia solution (50 ml_) and the aqueous phase was back extracted with more ethyl acetate (4 x 20 ml_). The combined organic phases were dried over anhydrous sodium sulphate, filtered and the solvent was removed in vacuo. The crude material was purified by chromatography on silica gel (ethyl acetate: heptane 1 :5 to 1 :1 to ethyl acetate: methanol 95:5) to afford the title compound as a bright yellow solid (80 mg).LCMS (run time = 4.5 min): Rt = 2.76 min; m/z 522; 524 [M+H]+., 55687-02-0

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER LIMITED; MILBANK, Jared Bruce John; PRYDE, David Cameron; TRAN, Thien Duc; WO2011/4276; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76982-23-5,5-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

76982-23-5, (1) In a 250mL three-neck bottle,Pass in nitrogen,Add 0.02mol of raw materials I-8 and dissolve in 100ml of tetrahydrofuran (THF).0.024mol bis (pinacolate) diboron,0.0002mol (1,1′-bis (diphenylphosphine) ferrocene) dichloropalladium (II) and 0.04mol potassium acetate were added, the mixture was stirred, and the mixed solution of the above reactants was heated to reflux at a reaction temperature of 80 C 5 hours; after the reaction is completed, cool and add 100 ml of water, and filter the mixture, take the filter cake and dry in a vacuum oven. The obtained residue was separated and purified through a silica gel column to obtain intermediate E3; the purity by HPLC was 99.1%, and the yield was 86.3%

76982-23-5 5-Bromoquinoxaline 610437, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Li Chong; Cai Xiao; Tang Dandan; Zhang Zhaochao; (70 pag.)CN110878092; (2020); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

76982-23-5, 5-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76982-23-5, A mixture of 5-bromoquinoxaline (300 mg, 1.43 mmol, 1 eq), potassium [2- (benzyloxy)ethyl]-trifluoroboranuide (695 mg, 2.87 mmol, 2 eq), Pd(OAc)2 (65 mg, 0.29 mmol, 0.2 eq), Butyldi-l-adamantylphosphine (103 mg, 0.29 mmol, 0.2 eq) and Cs2C03 (1169 mg, 3.59 mmol, 2.5 eq) in Toluene (4 mL) and H20 (1 mL) was stirred overnight at 100 C. The reaction was quenched with water and extracted with EtOAc. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with petroleum ether/EtOAc to afford 5-[2-(benzyloxy)ethyl]quinoxaline (321 mg, 85%) as a yellow oil. LCMS: m/z = 265.1 [M+H]+.

The synthetic route of 76982-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIPELINE THERAPEUTICS, INC.; XIONG, Yifeng; SCHRADER, Thomas; CHEN, Austin; ROPPE, Jeffrey Roger; BACCEI, Jill Melissa; BRAVO, Yalda; (199 pag.)WO2019/241131; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

The title compound was prepared from 6-Bromo-2-chloro-quinoxaline (3 g, 12.32 mmol) using the method applied for example 5 with the following exceptions: (1 ) in step 1 , 1-Methyl-1-phenyl-ethylamine (1.99 g, 14.72 mmol) was used instead of (R)-1 -(3-Fluoro-phenyl)-ethylamine and Nu,Nu-Diisopropylethylamine (8.4 mL, 6.23 g, 48.23 mmol) was used instead of trimethylamine (2) Title product was isolated as the free base. Yield of final step: 0.04 g (41 %)., 55687-02-0

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert George; WALKER, David Winter; (166 pag.)WO2016/170163; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-bromo, 2-chloroquinoxaline (0.700 g, 2.8 mmol) and Triethylamine (0.87 g, 8.6 mmol) were dissolved in DMSO (15 mL) at room temperature and (f?)-1-(3-Fluoro-phenyl)- ethylamine hydrochloride (0.400 g, 2.8 mmol) was added. The reaction mixture was stirred at RT for 16 hours. After completion of reaction (confirmed by TLC), water (10OmL) was added to the reaction mixture and it was extracted with ethyl acetate (50 mL x 3). The organic layer was washed with water (15 mL), brine (15 mL), and was then dried over Na2SO4. The organic layer was concentrated in vacuo to afford the crude product.The crude product was adsorbed on silica gel and was purified by column chromatography using neutral silica gel of 60-120 mesh size. Methanol (1-1.5 %) was used as a gradient in DCM for elution of the title compound as a solid (0.35 g, 36%)., 55687-02-0

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (2.78 g, 0.01 mol) in DMF (50 mL), 4-(trifluoromethyl)aniline (1.61 g, 0.01 mol) was added. The reaction mixture was refluxed for 24 h. After completion of the reaction, the reaction mixture was poured onto crushed ice with stirring. Then, the solid residue that formed was filtered, washed with water, dried and crystallized from petroleum ether (80-100C) to give 4. Yield: 40%; (brown powder): m.p. 157-159 O C;IR (KBr, cm -1 ): 3158 (NH), 1603 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 7.25-7.82 (m, 7H, Ar-H), 9.71(s, br, 1H, NH; exchangeable with D 2 O). 13 C NMR(DMSO-d 6 , delta , ppm): 121.15-147.09 (12Ar-C, CF 3 ),152.69, 152.86 (2C=N). MS (m/z), 336 (M + -C 2 H 3 F 2 ; 100%), 401 (M + ; 88%), 402 (M + + 1; 60%),403 (M + + 2; 57%), 404 (M + + 3; 62%), 405 (M + + 4;52%). Analysis: calcd. for C 15 H 8 BrClF 3 N 3 (402.60):C, 44.75; H, 2.00; N, 10.44%; found: C, 44.61; H,2.26; N, 10.69%.

108229-82-9, 108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider