Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98416-72-9,6-Bromo-2-chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.,98416-72-9

4.11 6-Bromo-3-methyl-2-(phenylthio)quinoxaline (11) To a solution of thiophenol (0.01 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) was added and refluxed for 1 h, then (5, 0.01 mol) was added and the mixture was further refluxed for 12 h (monitored by TLC). After completion of the reaction, the mixture was filtered and the excess of acetonitrile was evaporated under reduced pressure, dried, crystallized from petroleum ether and purified by a silica gel column chromatography (chloroform) to produce crude product. Yield: 78%; (brown powder): mp 59-61 C; IR (KBr) numax in cm-1: 2956, 2851 (aliphatic C-H), 1597 (C=N); 1H NMR (DMSO-d6, 500 MHz): delta 2.65 (s, 3H, CH3), 7.40-7.80 (m, 8H, Ar-H); 13C NMR (DMSO-d6, 125 MHz): delta 20.55 (CH3), 114.23-133.21 (12Ar-C), 154.60, 154.64 (2C=N); MS (m/z), 109 (M+-C9H7N2; 100%), 330 (M+; 3%), 331 (M++1; 6%), 332 (M++2; 3%). Anal. Calcd for C15H11BrN2S (331.23): C, 54.39; H, 3.35; N, 8.46. Found: C, 54.39; H, 3.35; N, 8.46.

98416-72-9 6-Bromo-2-chloro-3-methylquinoxaline 13487186, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
Quinoxaline – Wikipedia
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887590-25-2, tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7.1: tert-Butyl ester of 4-(5-bromo-pyridin-2-yl)-3,4-dihydro-2H-quinoxaline-1-carboxylic acid16 g of tert-butyl ester of 3,4-dihydro-2H-quinoxaline-1-carboxylic acid is put in a 1-liter three-necked flask, under nitrogen atmosphere. 325 ml of pyrrolidinone and 14.70 ml of 5-bromo-2-fluoropyridine are added. It is cooled in an ice bath. 15.93 g of potassium tert-butylate is added a little at a time. The reaction mixture is stirred cold for 1 h, then the reaction mixture is allows to return to room temperature. It is stirred for 1 h. It is cooled in an ice bath and is hydrolyzed slowly. The organic phase is extracted with ethyl ether. The combined organic phases are washed with water, then with saturated NaCl solution. The reaction mixture is dried, with stirring, over Na2SO4, then filtered on a frit and concentrated under reduced pressure. 10.1 g of tert-butyl ester of 4-(5-bromo-pyridin-2-yl)-3,4-dihydro-2H-quinoxaline-1-carboxylic acid is obtained in the form of a white solid, after purification on a silica column (heptane/EtOAc gradient: 5 to 20% of EtOAc).M+H+=392, 887590-25-2

As the paragraph descriping shows that 887590-25-2 is playing an increasingly important role.

Reference£º
Patent; SANOFI; US2012/165337; (2012); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.,50998-17-9

To a solution of 11g (30 mg, 113 mumol), 6-bromoquinoxaline (36 mg, 172 mol), Bu4NOAc (66.2 mg, 220 mol) and Pd(OAc)2 (3.7 mg, 16.5 mol) in NMP (0.5 mL ). The reaction mixture was stirred for 32 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure. Diluted with water and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12g (6.1 mg, 14%) as a pale yellow solid. TLC: Rf 0.3 (1:1 hexane/EtOAc). mp: 133136 oC. 1H-NMR (400 MHz, CDCl3) delta 8.83 (d, 1H, J = 2.0 Hz), 8.80 (d, 1H, J = 2.0 Hz), 7.99 (d, 1H, J = 8.8 Hz), 7.92 (d, 1H, J = 2.0 Hz), 7.75 (t, 1H, J = 8.0 Hz), 7.65-7.62 (m, 3H), 7.33 (m, 1H), 7.17 (d, 1H, J = 8.0 Hz), 7.03 (td, 1H, J = 8.0 Hz, J = 1.2 Hz), 6.78 (d, 1H, J = 8.0 Hz), 3.27 (s, 3H), 2.27 (s, 3H). 13C-NMR (100 MHz, CDCl3) delta 158.5, 156.7, 149.4, 145.6, 145.5, 144.2, 142.7, 142.6, 139.2, 134.1, 132.1, 131.9, 131.8, 130.5, 130.1, 128.6, 123.9, 121.1, 119,6, 116.1, 111.2, 54.8, 23.9. HRMS (ESI) calcd. for C23H19N6O (M+H): 395.1615; found 395.1620.

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

98416-72-9, 6-Bromo-2-chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of amino compound and K2CO3 (2.0 g) in acetonitrile(50 mL), compound 5 (0.01 mol) was added and the mixturewas refluxed for an appropriate time (16-20 h) (monitored byTLC). After completion of the reaction, the mixture was filteredand the excess of acetonitrile was evaporated under reduced pressureto get the product. The product was crystallized from benzeneto afford the corresponding compounds, 98416-72-9

98416-72-9 6-Bromo-2-chloro-3-methylquinoxaline 13487186, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The reaction was conducted under the stream of argon. Into a 20 ml two-necked flask, 600 mg of molecular sieves 5A was placed and stirred under heating under a reduced pressure sufficiently. To the above, 48.4 mg (FW: 915.70; 0.0528 mmole) of Pd2(dba)3, 0.212 mmole (FW: 202.3; 78.6 mul as a 2.7 M toluene solution) of tBu3P, 710 mg (FW: 96.11; 7.39 mmole) of Na(OtBu) and 1.96 g (FW: 33.644; 5.82 mmole) of N,N-diphenyl-N’-phenyl-p-phenylenediamine were added. Then, 16 ml of toluene as the solvent was added, and the resultant mixture was sufficiently stirred. To the resultant mixture, 767 mg (FW: 289.94; 2.64 mmole) of 5,8-dibromoquinoxaline was added, and the reaction was allowed to proceed under the refluxing condition (about 120C) for 6 hours. The reaction product was filtered through Celite and sufficiently washed with ethyl acetate. The obtained product was purified in accordance with the silica gel column chromatography (the developing solvent: methylene chloride). As the result, 1.74 g (the yield: 83%) of the object product (Compound (1)) was obtained (the Rf value: about 0.5). The obtained product was analyzed in accordance with FD-MS, and the major ion peak was found at 798, which agreed with the calculated value. The glass transition temperature as measured in accordance with the differential scanning calorimetry (DSC) was 138.6C, and the ionization potential was 5.3 eV.

148231-12-3, 148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; IDEMITSU KOSAN CO., LTD.; EP1749823; (2007); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1233318-23-4,Methyl 2-(quinoxalin-6-yl)acetate,as a common compound, the synthetic route is as follows.

To dimethyl carbonate (30 mL) cooled at 0 was added potassium tert-butanolate (3.8 g, 34.12 mmol) in portions. The resultant mixture was stirred at 0 for 1 hour. Methyl 2- (quinoxalin-6-yl) acetate (2.3 g, 11.37 mmol) was added. The resultant mixture was slowly warmed up to room temperature and stirred for 1 hour. The reaction mixture was heated to 90 and stirred for 1.5 hours. After cooling to room temperature, the mixture was diluted with EtOAc (150 mL) , washed with saturated NH4Cl (80 mL) and brine (50 mL) , dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by flash column (petroleum ether/ethyl acetate3: 1) to obtain dimethyl 2- (quinoxalin-6-yl) malonate (2.0 g) as a yellow solid. 1H NMR (CHLOROFORM-d) : delta 8.89 (s, 2H) , 8.10 -8.19 (m, 2H) , 7.91 (dd, J 8.7, 2.0 Hz, 1H) , 4.95 (s, 1H) , 3.82 (s, 6H) . LC-MS: m/z 261.1 (M+H) +., 1233318-23-4

As the paragraph descriping shows that 1233318-23-4 is playing an increasingly important role.

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Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy, M.; KONTEATIS, Zenon, D.; SUI, Zhihua; YE, Zhixiong; (199 pag.)WO2018/39972; (2018); A1;,
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49679-45-0,49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1B) Method B: A suspension of ethyl 3-chloroquinoxaline-2-carboxylate (11.5 g, 48.6 mmol), trimethylboroxine (6.06 g, 48.6 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (1.98 g, 2.42 mmol), and potassium carbonate (13.4 g, 97.0 mmol) in 1,4-dioxane (162 mL) was heated for 4.5 hour at 115 C. After being cooled to ambient temperature, the reaction mixture was filtrated through celite with ethyl acetate (500 mL). The filtrate was combined and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1 to 2:1) followed by recrystallization from ethanol-water (1/4) to give ethyl 3-methylquinoxaline-2-carboxylate as colorless crystals (8.36 g, 80%). mp 74-75 C. MS (APCI): m/z 217 (M+H).

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

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Patent; Kawanishi, Eiji; Matsumura, Takehiko; US2011/160206; (2011); A1;,
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50998-17-9,50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 13A 1-Quinoxalin-6-yl-ethanone A solution of 6-bromo-quinoxaline (261 mg, 1.25 mmol), 1-ethoxyvinyltri-n-butyltin (0.47 mL, 1.4 mmol), palladium(II) acetate (16 mg) and tri-t-butylphosphonium tetrafluoroborate (41 mg) in anhydrous DMF (4 mL) under a nitrogen atmosphere was heated at 120 C. for 1 hr. The reaction mixture was cooled to ambient temperature and partitioned between ethyl acetate (25 mL) and H2O (10 mL). The organic extraction was washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was chromatographed on silica gel eluding with ethyl acetate:hexanes (1:1) to provide 110 mg of the title compound. 1H NMR (300 MHz, CDCl3) delta 2.79 (s, 3H), 8.18 (d, J=9 Hz, 1H), 8.36 (dd, J=9 Hz, J=3 Hz, 1H), 8.70 (d, J=3 Hz, 1H), 8.95 (s, 2H); MS (DCl/NH3) m/z 173 (M+H)+.

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-Yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.; US2005/272736; (2005); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

To a solution of 11b (103.8 mg, 451 mumol), 6-bromoquinoxaline (142 mg, 679 mumol), Bu4NOAc (271 mg, 0.9 mmol) and Pd(OAc)2 (15.2 mg, 67.5 mol) in NMP (0.9 mL). The reaction mixture was stirred for 22 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure, diluted with water, and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12b (91 mg, 56%) as a pale yellow solid. TLC: Rf 0.37 (1:1 hexane/EtOAc). mp: 96.0-98.0 oC. 1H-NMR (400 MHz, CDCl3) delta 8.90 (AB quartet, 2H, J = 2.0 Hz), 8.09 (d, 1H, J = 8.8 Hz), 8.07 (d, 1H, J = 2.0 Hz) 7.72 (t, 1H, J = 8.0 Hz), 7.63 (dd, 1H, J = 8.8 Hz, J = 2.0 Hz), 7.60 (d, 1H, J = 8.0 Hz), 7.12(d, 1H, J = 8.0 Hz), 2.80 (m, 2H), 2.20 (s, 3H), 1.69-1.60 (m, 3H), 0.86 (d, 6H, J = 6.4 Hz). 13C-NMR (100 MHz, CDCl3) delta 158.2, 149.3, 147.8, 145.9, 145.8, 142.8, 142.7, 139.1, 132.6, 132.2, 131.0, 130.4, 129.2, 123.5, 115.2, 38.7, 27.8, 23.8, 23.1, 22.5. HRMS (ESI) calcd. for C21H23N6 (M+H): 359.1979; found 359.1983., 50998-17-9

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (2.78 g, 0.01 mol) in acetic acid (50 mL), o-phenylenediamine (1.62 g,0.015 mol) was added and the reaction mixture was refluxed for 7 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried, crystallized fromethanol and purified by column chromatography using an elution system chloroform : methanol (10 :0.3, v/v) to give the product. Yield: 77%; (yellow powder): m.p. over 300C; IR (KBr, cm -1 ): 3182, 3112 (2NH), 1605 (C=N).1 H NMR (DMSO-d 6 , delta , ppm): 7.30-7.96 (m, 7H, Ar-H), 11.63, 11.70 (2s, br, 2H, 2NH; exchangeablewith D 2 O). 13 C NMR (DMSO-d 6 , delta , ppm): 114.43-143.23 (12Ar-C), 144.88, 145.03 (2C=N). MS(m/z), 312 (M + ; 100%), 313 (M + + 1; 23%), 314 (M ++ 2; 99.9%). Analysis: calcd. for C 14 H 9 BrN 4(313.15): C, 53.70; H, 2.90; N, 17.89%; found: C,53.92; H, 2.79; N, 18.04%., 108229-82-9

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
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