Tag: M.W:200-300

55687-02-0,55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 4 4-(4-((6-Bromo-2-quinoxalinyl)oxy)phenoxy)-2-penten-1-ol STR17 A mixture of 3.76 g (15.4 mmol) of 6-bromo-2-chloroquinoxaline, 3.00 g (15.4 mmol) of 4-(4-hydroxy- phenoxy)-2-penten-1-ol, 2.34 g (16.9 mmol) of powdered, anhydrous potassium carbonate and 50 ml of dry dimethylsulfoxide was stirred at room temperature for a period of 24 hours. The mixture was poured over ice and extracted three times with ether. The combined ether layers were washed with 1 percent aqueous sodium hydroxide, then with water, dried over MgSO4 and evaporated to dryness. The residue was recrystallized from toluene to give 2.50 g of the desired pentenol as a yellow solid. (Compound D).

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The Dow Chemical Company; US4900354; (1990); A;,
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55687-34-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-34-8,6-Bromoquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

EXAMPLE 2 6-Bromo-1-ethoxycarbonylmethylquinoxaline-2,3(1H,4H)-dione Under a nitrogen atmosphere 6-bromoquinoxalin-2(1H)-one (2.03 g, 9 mmol) (J.Med.Chem., 24 , (1981), 93) was dissolved in 22 ml of dry DMF and sodium hydride (0.44 g, 10.8 mmol (60% mineral oil dispersion)) was added. After stirring for 2 h, ethyl bromoacetate (1.25 ml, 11.3 mmol) was added and the mixture was stirred for 3.5 h. The reaction mixture was poured onto crushed ice and acidified (PH = 4.5) by addition of dilute hydrochloric acid. The precipitate was filtered off, washed with water and air dried. The crude product (containing a minor fraction of O-alkylated product) was triturated with ether (100 ml), the precipitate filtered off, washed with ether and dried to afford 1.95 g (80%) of pure 6-bromo-1-ethoxycarbonylmethylquinoxalin-2(1H)-one. 1-NMR (DMSO-d6: delta 1.22 (t, 3H), 4.17 (q, 2H), 5.08 (s, 2H), 7.56 (d, 1H), 7.83 (dd, 1H), 8.09 (dd, 1H), 8.37 (s, 1H). The above ester (1.25 g; 4 mmol) was reacted with 30% H226 ml) in glacial acetic acid (16 ml) at 55C for 2 h. The mixture was cooled, the precipitate filtered off and recrystallized from dilute acetic acid to afford 1.0 g (77%) of the title compound . M.p. 282-83C. 1-NMR (DMSO-d6: delta 1.22 (t, 3H), 4.17 (q, 2H), 4.92 (s, 1H), 7.33 (m, 3H), 12.24 (br.s, 1H).

55687-34-8 6-Bromoquinoxalin-2(1H)-one 12686394, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NOVO NORDISK A/S; EP520024; (1996); B1;,
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82019-32-7,82019-32-7, 7-Bromo-1-methyl-1H-quinoxalin-2-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 50 mL open round bottom flask equipped with a magnetic stir bar, add compound (II) 7-bromo-1-methylquinoxaline-2-one (95.2 mg, 0.4 mmol),Rhodamine 6G (9.6mg, 0.02mmol), ethyl mercaptan (124.3mg, 2mmol),Trifluoroacetic acid (91 mg, 0.8 mmol), the mixture was dissolved in DMF (5 ml), and irradiated with 3W blue light, and the reaction was stirred at 25 C. for 24 hours. The reaction mixture was quenched with a saturated aqueous NaHCO 3 solution and washed with water.The mixture was extracted with ethyl acetate, and the combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure.The crude product was purified on a silica gel column using n-hexane / ethyl acetate to obtain the product.7-bromo-3- (ethylthio) -1-methylquinoline-2 (1H) -one (I-a) 88.03 mg, yield 74.1%, HPLC purity 97.6%.

The synthetic route of 82019-32-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhejiang University of Technology; Li Jianjun; Zhou Jiadi; Zhou Peng; Zhao Tingting; (7 pag.)CN110590684; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49679-45-0,Ethyl 3-chloroquinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

49679-45-0, General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2). 4.1.1.1. Ethyl 3-(phenylethynyl)quinoxaline-2-carboxylate (2a) Yellowsolid; mp 109 C. 1H NMR (200 MHz, CDCl3) = delta (ppm) 1.48 (t,J = 7.1 Hz, 3H), 4.60 (q, J = 7.1 Hz, 2H), 7.37-7.43 (m, 3H), 7.66-7.69(m, 2H), 7.77-7.88 (m, 2H), 8.11-8.20 (m, 2H). 13C NMR (50 MHz,CDCl3) = delta (ppm) 14.2, 62.6, 86.1, 96.0, 121.5, 128.4 (3), 128.8, 129.7(2), 131.1, 132.2, 132.3, 137.2,139.3, 142.3, 146.1, 164.4. Anal. Calcd forC19H14N2O2: C, 75.48; H, 4.67; N, 9.27. Found: C, 75.71; H, 4.52; N,9.21.

49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

49679-45-0, Step G (Compound 7) [00142] Compound 6 (1.6 g. ) was dissolved in ethanol (32.0 ml. ). The reaction mixture was cooled to approximately-50 degrees via an acetone/dry ice bath. Ammonia (g) was bubbled into the solvent for approximately 30 seconds and the glass vessel was capped. The bath was removed and the reaction mixture was allowed to gradually rise to room temperature where it was stirred overnight. The reaction mixture was re-cooled to-50 degrees (as above) and the glass vessel was opened. After allowing to warm to room temperature, the solid product was collected by filtration. After washing with a small amount of cool ethanol, the product was dried under reduced pressure. Yield: 720 mg. , approximately 52%. 1H NMR (500 MHz, CDC13) 5 8.16 (d, 1H), 8.08 (d, 1H), 7.97-7. 87 (m, 2H).

As the paragraph descriping shows that 49679-45-0 is playing an increasingly important role.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2005/56547; (2005); A2;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) To a solution of ethyl 3-chloroquinoxaline-2-carboxylate (see J. Chem. Soc. 1945, 622; 12.3 g, 52.0 mmol) and triethylamine (8.70 mL, 62.4 mmol) in N,N-dimethylformamide (52 mL) was added aqueous dimethylamine (50%, 6.60 mL, 62.7 mmol) at room temperature. After being stirred for 3 hour at room temperature, the reaction mixture was poured into water (500 mL), and the mixture was extracted with ethyl acetate (2000 mL). The organic layer was washed with water, dried over sodium sulfate, filtrated and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give ethyl 3-(dimethylamino)quinoxaline-2-carboxylate as a pale yellow oil (12.6 g, 99%). MS (APCI): m/z 246 (M+H).

49679-45-0, 49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Kawanishi, Eiji; Matsumura, Takehiko; US2011/160206; (2011); A1;,
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50998-18-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-18-0,6-Iodoquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: Arene (0.10 mmol, 1.0 equiv), Pd(OAc)2 (2.2 mg, 10 mumol,10 mol%), ligand (15 mol% or 20 mol%), hydrogen phosphate (15 mol% for benzylamine substrate), aryl iodide (0.3 mmol, 3.0 equiv.) and silver acetate (50 mg, 0.30 mmol, 3.0 equiv.) were added into a 2-dram reaction vial. Solvent and (+)-NBE-CO2Me (20 mol% or 50 mol%) were added to the mixture. The vial was flushed with N2 and capped. The reaction mixture was then stirred at the selected temperature for 12-24 h. After cooling to room temperature, the mixture was filtered through Celite and eluted with ethyl acetate. The filtrate was evaporated under reduced pressure. Purification by preparative thin-layer chromatography afforded the desired product.

As the paragraph descriping shows that 50998-18-0 is playing an increasingly important role.

Reference£º
Article; Shi, Hang; Herron, Alastair N.; Shao, Ying; Shao, Qian; Yu, Jin-Quan; Nature; vol. 558; 7711; (2018); p. 581 – 585;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-34-8,6-Bromoquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

To a stirred solution of the compound obtained from Preparation 29 (2 g, 8.89 mmol) in phosphorus oxychloride (15 mL), was added DMF (1 mL). The mixture was stirred at 120C for 1.5 hours then allowed to cool to room temperature. The dark solution was concentrated in vacuo and cautiously quenched with crushed ice. The aqueous suspension was neutralised with 10% potassium carbonate solution and extracted with DCM (2 x 30 mL). The combined organic phases were dried (Na2SO4), filtered and concentrated to give 1.94 g of the title compound as a brown solid.1H-NMR (400 MHz, DMSOd6): delta= 9.02(1 H, s), 8.40(1 H, d), 8.06(1 H, dd), 7.98(1 H, d). LCMS (run time = 2min): R4 = 1.69 min; m/z 243; 245 [M+H]+, 55687-34-8

As the paragraph descriping shows that 55687-34-8 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; MILBANK, Jared Bruce John; PRYDE, David Cameron; TRAN, Thien Duc; WO2011/4276; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76982-23-5,5-Bromoquinoxaline,as a common compound, the synthetic route is as follows.,76982-23-5

Under a nitrogen atmosphere, the compound of formula C (0.658 g, 3.30 mmol), The compound of formula D (1.518 g, 7.26 mmol), Sodium tert-butoxide (0.952 g, 9.90 mmol), Bis (dibenzylideneacetone) palladium (0) (0.114 g), bis (diphenylphosphino) – 1,1′-binaphthalene (0) 100 mL of toluene was added to [(¡À) -2,2′-Bis (diphenylphosphino) -1,1′-binaphthalene] (0.185 g, 0.297 mmol) and refluxed for 12 hours. After the temperature was lowered to room temperature, the mixture was washed with water, the residue was removed with MgSO 4, hydrazine monohydrate was added thereto, and the mixture was stirred at room temperature for 30 minutes. Precipitated in hexane, filtered off the solid, and dried under vacuum to obtain the compound 2

As the paragraph descriping shows that 76982-23-5 is playing an increasingly important role.

Reference£º
Patent; LG Chem, Ltd.; Kim Jin-seok; Bae Jae-sun; Lee Jae-cheol; Shin Hyeon-a; Hwang Min-ho; Ryu So-yeong; Jeong Se-jin; (36 pag.)KR2019/5591; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

Under nitrogen protection,The diprazole pyrene intermediate 100 mmol,2-bromoquinoxaline 223 mmol,Tris (dibenzylideneacetone) dipalladium 5.0 mmol,Sodium tert-butoxide,Tri-tert-butylphosphine (20.1 mmol) was placed in a reaction vessel,And dissolved in 500 ml of toluene,110 reflux reaction 24h,The reaction end point was determined by thin layer chromatography (TLC)After completion of the reaction, the mixture was cooled to room temperature, passed through a silica gel funnel, washed with methylene chloride, spin dried, recrystallized from dichloromethane / petroleum ether,After drying, 81 mmol of compound 15 was obtained in 81% yield.

36856-91-4, As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Shanghai Keliente Chemical Materials Co., Ltd.; Yin Enxin; Lin Wenjing; (17 pag.)CN104262347; (2017); B;,
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