Tag: M.W:200-300

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 16 2-[(Butylamino)(butylimino)methylthio]-3-quinoxalinecarboxylic acid ethyl ester, hydrochloride 2-Chloro-3-quinoxalinecarboxylic acid ethyl ester (7.10 g., 0.03 mole) was dissolved in 125 ml. of acetone treated with Norit and filtered. The filtrate was added to 5.650 g. (0.03 mole) of 1,3-di-n-butylthiourea in 100 ml. of acetone. The solution was stirred at reflux under a nitrogen atmosphere for 6 hours, allowed to cool to room temperature, and stirred an additional 17 hours. The red solution was treated with Norit, filtered, and concentrated to a volume of 100 ml. The yellow solid that crystallized out was collected by filtration, washed and dried to give the 6.05 g. (47.5% yield) of product, m.p. 138-139 C. (dec.). Analysis for: C20 H29 ClN4 O2 S Calculated: C, 56.52; H, 6.88; N, 13.18; Cl, 8.34. Found: C, 56.74; H, 6.78; N, 13.25; Cl, 8.09.

49679-45-0, The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
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36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under the protection of nitrogen,Weighing compound S5 (15 mmol), S17 (15 mmol), [Pd2(dba)3]¡¤CHCl3(0.3 mmol) and HP(tBu)3¡¤BF4 (0.6 mmol),Add to a 100 mL two-necked flask.Inject 30 mL of toluene into the two-necked flask (pre-pass N2 for 15 min to remove oxygen).Then, 3.6 mL of a 1 M aqueous solution of K2CO3 (previously passed N2 for 15 min to remove oxygen) was added dropwise, and stirred at room temperature overnight.After the reaction was over, 50 mL of deionized water was added.Then add a few drops of 2M HCl. Extract with dichloromethane.Collect organic phase,It was dried over anhydrous Na2SO4.Filter the dried solution,The solvent was removed using a rotary evaporator to give a crude material.The crude product was purified by silica gel column chromatography.Final purification gave solid P4 (13.2 mmol, 88%)., 36856-91-4

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Shanghai Tianma Organic Shine Display Co., Ltd.; Gao Wei; Wang Xiangcheng; Zhang Lei; Niu Jinghua; (47 pag.)CN108358905; (2018); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

108229-82-9, To a solution of compound 1 (0.28 g, 1 mmol) in absolute ethanol (50 mL), hydrazine hydrate90% (0.07 mL, 1.5 mmol) was added and the reaction mixture was stirred in an ice bath at 0 C for 2 h.After completion of the reaction, the precipitate that formed was filtered, dried and the crude productwas further purified by a silica gel column chromatography (chloroform) to give the product. Yield:61%; (red-brown powder): mp 201-203 C; IR (KBr) max in cm1: 3415, 3250, 3146 (NH2, NH), 1598(C=N); 1H-NMR (DMSO-d6): 5.00 (s, br, 2H, NH2; exchangeable with D2O), 7.37-7.79 (m, 3H, Ar-H),9.16 (s, br, 1H, NH; exchangeable with D2O); 13C-NMR (DMSO-d6): 124.68, 129.67, 130.02, 134.78,138.98, 140.60 (6Ar-C), 145.22, 145.85, (2C=N); MS (m/z), 64 (M+ C4H4BrClN3; 100%), 272 (M+; 5%),273 (M+ + 1; 21%), 274 (M+ + 2; 17%), 275 (M+ + 3; 3%), 276 (M+ + 4; 5%). Anal. Calcd. for C8H6BrClN4(273.52): C, 35.13; H, 2.21; N, 20.48%. Found: C, 34.97; H, 2.45; N, 20.34%.

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Al-Marhabi, Aisha R.; Abbas, Hebat-Allah S.; Ammar, Yousry A.; Molecules; vol. 20; 11; (2015); p. 19805 – 19822;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 10 2-(Aminoiminomethylthio)-3-quinoxalinecarboxylic acid ethyl ester, hydrochloride 2-Chloro-3-quinoxalinecarboxylic acid ethyl ester (9.5 g., 0.04 mole) and 3.052 g. (0.04 mole) of thiourea were dissolved in 200 ml. of acetone. The solution was boiled in an open flask for 11/2 hours during which acetone was added to maintain the volume at 200 ml. The reaction mixture was cooled and the solid was collected by filtration to give 7.8 g. of crude product. Recrystallization from methanol-acetone afforded 3.55 g. of off-white solid, over wide range dec. Analysis for: C12 H13 ClN4 O2 S Calculated: C, 46.08; H, 4.19; N, 17.91; Cl, 11.33; S, 10.25. Found: C, 46.01; H, 4.13; N, 17.85; Cl, 11.38; S, 10.32. An additional 4.05 g. of product was recovered from the reaction mixture to give a total yield of 7.60 g. (59.3%). Found: C, 46.06; H, 4.14; N, 17.79; Cl, 11.38; S, 10.37

49679-45-0, As the paragraph descriping shows that 49679-45-0 is playing an increasingly important role.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

A slurry of 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-(7-azaspiro[3.5]non-1-en-2-yl)isoxazole (25 mg, 0.07 mmol, synthesis described in General Method A), 6-bromo-2-chloroquinoxaline (19.5 mg, 0.08 mmol) and Cs2CO3 (43.4 mg, 0.13 mmol) in dioxane (0.3 mL) was degassed by bubbling nitrogen through the mixture for 5 minutes. Chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) (RuPhos-Pd-G2) (2.59 mg, 3.33 mumol) was added and the reaction mixture was sealed and heated to 90C. for 6 hours. The crude reaction mixture purified directly by flash chromatography on SiO2 (0-100% EtOAc/hexanes, Isco 12 g column) to yield 4-(7-(6-bromoquinoxalin-2-yl)-7-azaspiro[3.5]non-1-en-2-yl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole (26 mg, 0.04 mmol, 64% yield) as a gum. 1H NMR (400 MHz, CDCl3) delta 8.57 (s, 1H), 8.03 (d, J=2.2 Hz, 1H), 7.64 (dd, J=8.8, 2.2 Hz, 1H), 7.53 (d, J=8.8 Hz, 1H), 7.46-7.42 (m, 2H), 7.40-7.34 (m, 1H), 5.80 (s, 1H), 3.94 (dt, J=13.5, 5.1Hz, 2H), 3.66-3.50 (m, 2H), 2.44 (s, 2H), 2.21 (tt, J=8.4, 5.1Hz, 1H), 1.76 (t, J=5.6 Hz, 4H), 1.36-1.30 (m, 2H), 1.22-1.15 (m, 2H)., 55687-02-0

Big data shows that 55687-02-0 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Carpenter, Joseph E.; Huang, Yanting; Wang, Ying; Wu, Gang; (137 pag.)US2019/127362; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-34-8,6-Bromoquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

55687-34-8, Compound 39 (600 mg, 2.66 mmol) was added to cold phosphorous oxychloride (4 mL) in portions wise to give a slurry. To the resulting slurry was added drop wise N,N- dimethylaniline (0.4 ml, 2.93 mmol) below 15C. The brick red mixture was refluxed for 15 min, and the resulting dark brown clear solution was then cooled to ambient temperature. It was added to ice cold water (40 mL) , and the mixture was basified slowly with 40% aq. NaOH to pH 8. The solid was collected by filtration, washed with water (2×10 mL) and dried to give the title compound 40 (70%) .

The synthetic route of 55687-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BANDYOPADHYAY, Anish; SARANGTHEM, Robindro; BARAWKAR, Dinesh; BONAGIRI, Rajesh; KHOSE, Goraksha; SHINDE, Shailesh; (226 pag.)WO2016/199943; (2016); A1;,
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354793-04-7, Methyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

354793-04-7, Step B DMF (5 drops) was added to a suspension of 2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid methyl ester (650 mg) in thionyl chloride (6.7 ML) at 23 C. The reaction mixture was then heated to reflux for 18 hrs.After cooling to 23 C. and concentration, the residue was dissolved in chloroform and washed sequentially with portions of saturated aqueous sodium bicarbonate and brine.Drying over sodium sulfate and concentration afforded 2,3-dichloro-quinoxaline-6-carboxylic acid methyl ester as a white solid. MS (M+H)+=257.1.

354793-04-7 Methyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate 23847563, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US2004/192698; (2004); A1;,
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98416-72-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98416-72-9,6-Bromo-2-chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

Method B: 4-(4-chlorobenzylideneamino)phenol (0.01 mol) wasdissolved in acetonitrile (50 mL). Anhydrous potassium carbonate(2.0 g) was added to the mixture, which was refluxed for 1 h, then(5, 0.01 mol) was added and the mixture was further refluxed for6 h (monitored by TLC). After completion of the reaction, the mixturewas filtered and the excess of acetonitrile was evaporatedunder reduced pressure to produce the compound, yield; 64%

The synthetic route of 98416-72-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, A solution of 6-bromo-quinoxaline (261 mg, 1.25 mmol), 1-ethoxyvinyltri-n-butyltin (0.47 mL, 1.4 mmol), palladium(II) acetate (16 mg) and tri-t-butylphosphonium tetrafluoroborate (41 mg) in anhydrous DMF (4 mL) under a nitrogen atmosphere was heated at 120 C. for 1 hr. The reaction mixture was cooled to ambient temperature and partitioned between ethyl acetate (25 mL) and H2O (10 mL). The organic extraction was washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was chromatographed on silica gel eluting with ethyl acetate:hexanes (1:1) to provide 110 mg of the title compound. 1H NMR (300 MHz, CDCl3) delta 2.79 (s, 3H), 8.18 (d, J=9 Hz, 1H), 8.36 (dd, J=9 Hz, J=3 Hz, 1H), 8.70 (d, J=3 Hz, 1H), 8.95 (s, 2H); MS (DCl/NH3) m/z 173 (M+H)+.

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.; US2005/256309; (2005); A1;,
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Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.212327-10-1,7-Bromo-2-methoxyquinoxaline,as a common compound, the synthetic route is as follows.

Under an argon atmosphere, 140 mg (0.586 mmol) of example 74A was dissolved in 15 ml dioxane. Then 172 mg (1.76 mmol) potassium acetate, 38 mg (0.047 mmol) of 1,1 ‘-bis- (diphenylphosphino)ferrocene palladium(II) chloride-dichloromethane complex and 163 mg (0.644 mmol) of 4,4,4’4l5,5,5’5′-octamethyl-2,2’-bi-l,3,2-dioxaborolan were added. The reaction mixture was stirred overnight at 1300C oil bath temperature. After cooling, dioxane was added to the reaction mixture and it was filtered on kieselguhr. It was washed again with ethyl acetate. The filtrate was concentrated in a rotary evaporator at reduced pressure and dried under high vacuum. We obtained 152 mg of 2-methoxy-7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)quinoxaline as raw product. This was reacted subsequently without further purification., 212327-10-1

As the paragraph descriping shows that 212327-10-1 is playing an increasingly important role.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan; WO2010/20363; (2010); A1;,
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