Some tips on 89891-65-6

The synthetic route of 89891-65-6 has been constantly updated, and we look forward to future research findings.

89891-65-6, 7-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of intermediate 431 ( 1 00 mg, 0.41 mmol) in dioxane (4 niL) and Nu.Eta2Omicron(10 mL, 25%) was stirred in a sealed tube at 1 10C overnight. The mixture was concentrated to give the crude intermediate 432 (108 mg) as a yellow solid., 89891-65-6

The synthetic route of 89891-65-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; WU, Tongfei; BREHMER, Dirk; BEKE, Lijs; BOECKX, An; DIELS, Gaston, Stanislas, Marcella; GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph; LAWSON, Edward, Charles; PANDE, Vineet; PARADE, Marcus, Cornelis, Bernardus, Catharina; SCHEPENS, Wim, Bert, Griet; THURING, Johannes, Wilhelmus, John, F; VIELLEVOYE, Marcel; SUN, Weimei; MEERPOEL, Lieven; (375 pag.)WO2017/32840; (2017); A1;,
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New learning discoveries about 55687-34-8

55687-34-8, The synthetic route of 55687-34-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-34-8,6-Bromoquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

[001023] Part C. Preparation of 6-bromo-2-chloroquinoxaline.; [001024] To a flask containing phosphorus oxychloride (3.4ml, 36.5mmol) was added the product fromPart B (255mg, l.lmmol) and the solution was heated at 6O0C overnight. The solution was cooled to room temperature, poured over ice and the resulting solid collected by filtration to give the title compound (239mg, 87%).

55687-34-8, The synthetic route of 55687-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
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Some tips on 50998-17-9

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

50998-17-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

To a solution of 11c (50 mg, 215 mumol), 6-bromoquinoxaline (66.9 mg, 320 mumol), Bu4NOAc (129 mg, 428 mumol) and Pd(OAc)2 (7.24 mg, 32.2 mumol) in NMP (0.5 mL ). The reaction mixture was stirred for 15 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure, diluted with water, and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12c (17 mg, 22%) as a yellow solid. TLC: Rf 0.22 (1:1 MeOH/CH2Cl2). 1H-NMR (400 MHz, CDCl3) delta 8.90 (d, 2H, J = 4.4 Hz), 8.09 (s, 1H), 8.08 (d, 1H, J = 8.0 Hz), 7.73 (t, 1H, J = 8.0 Hz), 7.63-7.60 (m, 2H), 7.13 (d, 1H, J = 8.0 Hz), 3.65 (t, 2H, J = 6.4 Hz), 2.85 (t, 2H, J = 7.6 Hz), 2.20 (s, 3H), 1.88 (quintet, 2H, J = 7.6 Hz), 1.65 (m, 2H), 1.58 (brs, 1H). 13C-NMR (100 MHz, CDCl3) delta 158.3, 149.2, 147.3, 145.8, 145.7, 142.8, 142.7, 139.1, 132.8; 132.1, 130.9, 130.4, 129.2, 123.6, 115.2, 62.4, 32.3, 25.7, 24.7, 23.8. HRMS (ESI) calcd. for C20H21N6O (M+H): 361.1771; found 361.1771.

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
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New learning discoveries about 36856-91-4

36856-91-4, 36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various fields.

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

c. Preparation of compound 6c A 25-mL round bottom flask equipped with a magnetic stirrer, a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline (13 mg, 0.063 mmol), boronate ester 6b (25 mg, 0.063 mmol), water/dioxane (1.0 mL/4.0 ml), K2C03 (17 mg, 0.126 mmol). The resulting solution was degassed for 15 min, then Pd(PPh3)4 (5 mg) was added. The reaction mixture was warmed to 100C and stirred for 1 h. After cooled to room temperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHC03, brine, dried over Na2S04. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with 10 % EtOAc/hexanes solvent system afforded the desired compound (15 mg, 60 % yield) . 1H NMR (300 MHz, CDC13) delta 9.46 (s, 1H), 8.83 (s, 1H), 8.69 (m, 1H), 8.46 (s, 1H), 8.21 (m, 2H), 7.86 (m, 2H), 7.72 (d, J =12.0 Hz, 2H), 7.58 (d, J= 12.0 Hz, 2H), 4.05 (s, 3H), 1.42 (s, 9H).

36856-91-4, 36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond, J.; PARHI, Ajit; PILCH, Daniel, S.; KAUL, Malvika; WO2013/106756; (2013); A2;,
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Downstream synthetic route of 55687-34-8

The synthetic route of 55687-34-8 has been constantly updated, and we look forward to future research findings.

55687-34-8, 6-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-34-8, [Reference Example 26] (0482) (0483) To the solution of 50 mg of 6-bromoquinoxalin-2(1H)-one in 0.5 mL ofN,N-dimethylacetamide, 26.4 muL of benzyl bromide and 61.4 mg of potassium carbonate were added at room temperature, and the resultant was stirred at room temperature for 30 minutes and at an external temperature of 50C for 30 minutes. The reaction mixture was cooled to room temperature, and water and ethyl acetate were then added thereto. The organic layer was separated and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate) to give 50 mg of 1-benzyl-6-bromoquinoxalin-2(1H)-one as a yellow solid. 1H-NMR (DMSO-d6) delta: 5.47 (2H, s), 7.20-7.38 (5H, m), 7.41 (1H, d, J = 9.2 Hz), 7.73 (1H, dd, J = 8.9, 2.3 Hz), 8.06 (1H, d, J = 2.6 Hz), 8.39 (1H, s).

The synthetic route of 55687-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Toyama Chemical Co., Ltd.; FUJIFILM Corporation; TANAKA, Tadashi; KONISHI, Yoshitake; KUBO, Daisuke; FUJINO, Masataka; DOI, Issei; NAKAGAWA, Daisuke; MURAKAMI, Tatsuya; YAMAKAWA, Takayuki; EP2915804; (2015); A1;,
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Analyzing the synthesis route of 49679-45-0

As the paragraph descriping shows that 49679-45-0 is playing an increasingly important role.

49679-45-0,49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2).

As the paragraph descriping shows that 49679-45-0 is playing an increasingly important role.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
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Analyzing the synthesis route of 36856-91-4

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 25-mL round bottom flask equipped with a magnetic stirrer, a condenser and a nitrogen inloutlet adapter was charged with 2-bromoquinoxaline (100 mg, 0.48 mmol),4-Fluorophenylboronic acid (80 mg, 0.57 mmol), water dioxane (1.0 mL4.0 ml), K2C03 (132 mg, 0.96 mmol). The resulting solution was degassed for 15 mm, then Pd(PPh3)4 (27 mg, 0.024 mmol) was added. The reaction mixture was warmed to 100 C. and stirred for 1 h. Afier cooled to roomtemperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHCO3, brine, dried over Na2504. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with EtOAc hexanes solvent system afforded the desired compound (40mg, 38% yield). 1H NMR (400 MHz, CDCl3) oe 9.34 (s, 1H),8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25 (m, 1H)., 36856-91-4

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Rutgers, The State University of New Jersey; LaVoie, Edmond J.; Parhi, Ajit; Pilch, Daniel S.; Kaul, Malvika; (36 pag.)US9822108; (2017); B2;,
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New learning discoveries about 82031-32-1

82031-32-1 7-Bromoquinoxalin-2(1H)-one 4913264, aquinoxaline compound, is more and more widely used in various fields.

82031-32-1, 7-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

82031-32-1, 6.00 mg (2.67 mmol) of 7-bromoquinoxalin-2(lH)-one [Lumma et al., J. Med. Chem. 1981, 24, 93] and 1.73 ml (3.47 mmol) trimethylsilyldiazomethane were taken up in 5.25 ml methanol/acetonitrile/dichloromethane (1/10/10). Then 0.483 ml (3.47 mmol) triethylamine was added and it was stirred overnight at room temperature. The mixture was concentrated by evaporation and the residue was purified by MPLC (Puriflash Analogix: 4OM: isohexane / ethyl acetate = 9 / 1 ? isohexane / ethyl acetate = 3 / 1). We obtained 140 mg (22% of theor.) of the target compound.LC-MS (method 10): R, = 1.09 min; MS (EIpos): m/z = 240 [M+H]+.IH-NMR (400 MHz, DMSO-D6): delta [ppm] = 4.04 (s, 3H), 7.78 (dd, IH), 7.96 (d, IH), 8.06 (d, IH), 8.64 (s, IH).

82031-32-1 7-Bromoquinoxalin-2(1H)-one 4913264, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan; WO2010/20363; (2010); A1;,
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Brief introduction of 55687-34-8

55687-34-8 6-Bromoquinoxalin-2(1H)-one 12686394, aquinoxaline compound, is more and more widely used in various fields.

55687-34-8, 6-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-34-8, EXAMPLE 2 6-Bromo-1-ethoxycarbonylmethylquinoxaline-2,3(1H,4H)-dione Under a nitrogen atmosphere 6-bromoquinoxalin-2(1H)-one (2.03 g, 9 mmol) (J.Med.Chem., 24, (1981), 93) was dissolved in 22 ml of dry DMF and sodium hydride (0.44 g, 10.8 mmol (60% mineral oil dispersion)) was added. After stirring for 2 h, ethyl bromoacetate (1.25 ml, 11.3 mmol) was added and the mixture was stirred for 3.5 h. The reaction mixture was poured onto crushed ice and acidified (pH=4.5) by addition of dilute hydrochloric acid. The precipitate was filtered off, washed with water and air dried. The crude product (containing a minor fraction of O-alkylated product) was triturated with ether (100 ml), the precipitate filtered off, washed with ether and dried to afford 1.95 g (80%) of pure 6-bromo-1-ethoxycarbonylmethylquinoxalin-2(1H)-one. 1 H-NMR (DMSO-d6):delta1.22 (t, 3H), 4.17 (q, 2H), 5.08 (s, 2H), 7.56 (d, 1H), 7.83 (dd, 1H), 8.09 (dd, 1H), 8.37 (s, 1H).

55687-34-8 6-Bromoquinoxalin-2(1H)-one 12686394, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Novo Nordisk A/S; US5166155; (1992); A;,
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New learning discoveries about 50998-17-9

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.,50998-17-9

Take 1mmol cp-2-19,Dissolved in 10ml anhydrous acetonitrile,0.05 mmol of Pd (OAc) 2,0.1 mmol of P (O-Tolyl) 3 and 3 mmol of Et3N were added,Then add 1.5mmol 6-bromoquinoxaline, Ar gas protection reaction 12h, after the reaction filter,After the filtrate was evaporated to dryness, the methylene chloride was dissolved, washed with water, washed with saturated NaCl, treated with anhydrous MgSO4,Silica gel column (PE: EA 50: 1) to give the compound

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Peking University; Fu, Hongzheng; Chen, Peng; (29 pag.)CN106543032; (2017); A;,
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