Tag: M.W:200-300

50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 216-(2-Chloropyridin-4-yl)quinoxalineA mixture of 6-bromoquinoxaline (1.07 g, 5.14 mmol), 2-chloropyridine-4- boronic acid (810 mg, 5.14 mmol), 2M aqueous sodium carbonate solution (5.5 mL, 11 mmol) and Pd(PPh3)4 (178 mg, 0.15 mmol) in DME (11 mL) was heated to 1200C in a sealed tube, under microwave irradiation, for 20 minutes. After cooling, the mixture was partitioned between water and EtOAc (100 mL each). The aqueous phase was extracted with EtOAc/THF (4: 1, 50 mL). The combined organic phases were dried (MgSO4) and concentrated in vacuo. The residue was washed with diethyl ether/THF (9: 1, 30 mL) to give the title compound (790 mg, 64%) as a brown solid. deltaH (CDCl3) 8.89-8.97 (m, 2H), 8.54 (d, IH), 8.39 (d, IH), 8.26 (d, IH), 8.03 (dd, IH), 7.72 (s, IH), 7.60 (dd, IH). LCMS (ES+) 242 (M+H)+, RT 2.87 minutes., 50998-17-9

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; WO2010/52448; (2010); A2;,
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36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

36856-91-4, 2-bromoquinoxaline 100mmol, eight membered nitrogen (or sulfur) heterocyclic boride intermediate 220mmol were added to 1L three-necked flask and dissolved in 400mL of toluene, was added under nitrogen tetrakistriphenylphosphine palladium 1.5mmol, 250mmol potassium carbonate, distilled water 100mL, the reaction was stirred at reflux for 24 hours, cooled to room temperature, after the reaction liquid separation, silica gel funnel, washing, spin-dry, recrystallized, filtered, 71mmol obtain compound 17 as a gray solid, yield 71%.

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Ma, Xiaoyu; Song, Qiaohong; Zhao, He; (22 pag.)CN105315229; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 17 By reaction of 2,3,6-trichloroquinoxaline with aminoacetaldehyde dimethyl acetal, according to a procedure that is similar to that followed in example 1, there is obtained 8-chloroimidazo[1,2-a]quinoxaline-4(5H)-one (m.p. >300 C.)., 2958-87-4

As the paragraph descriping shows that 2958-87-4 is playing an increasingly important role.

Reference£º
Patent; Biomedica Foscama Industria Chimicofarmaceutica S.p.A.; US6124287; (2000); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.887590-25-2,tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate,as a common compound, the synthetic route is as follows.

887590-25-2, A partial solution of tert-butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate (100 mg, 0.467 mmol), 1,3-dibromobenzene (220 mg, 0.933 mmol), C52CO3 (608 mg, 1.867 mmol) in toluene (1 mL), was purged and degassed with N2, then 2,2?- bis(diphenylphosphino)-1,1?-binaphthalene (58.1 mg, 0.093 mmol) and palladium(II) acetate (20.95 mg, 0.093 mmol) were added, and the vessel was purged and degassedagain. The reaction flask was capped and stirred at 110 C overnight. The mixture was cooled, water (15 mL) was added and extracted with ethyl acetate (15 mL x 3). The combined organic layers were washed with brine, dried over Na2504, and concentrated. The residue was purified on silica gel with a gradient of 0-100% EtOAc in hexanes to give tert-butyl 4-(3 -bromophenyl)-3 ,4-dihydroquinoxaline- 1 (2H)-carboxylate (120 mg66.1% yield) as a white solid. LCMS M = 389.10/391.15. Method G. Retention time4.175 mm.

The synthetic route of 887590-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; BATT, Douglas G.; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; LIU, Qingjie; MARCOUX, David; NEELS, James; POSS, Michael A.; QIN, Lan-ying; RUAN, Zheming; SHI, Qing; SRIVASTAVA, Anurag S.; TINO, Joseph A.; WATTERSON, Scott Hunter; (532 pag.)WO2016/64957; (2016); A1;,
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108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Sodium hydride (349 mg, 0.008792 mol, 1.2 eq) was added to a solution of 2-ethylbutyl 2-cyanoacetate (1.23 g, 0.007326 mol, 1.00 eq) in dry DMF (20 ml) at 0C under inert atmosphere. After 10 minutes, 2,3-dichloroquinoxaline (1.75 g, 0.008792 mol, 1.2 eq) was added and the reacting mixture was stirred overnight at 70C. The solution was cooled to 0C then diluted in sat. H4CI and extracted with DCM . The combined organic layers were dried over MgS0 , filtered and concentrated. Purification by column chromatography on silica gel (0 to 30% AcOEi/liexanes) provided 2-ethylbutyi 2-(3-chloroquinoxalin-2-yl)-2-cyanoacetate as a yellow solid (2.20 g, 74% yield). A solution of (Z)-2-ethylbutyl 2-(3-chloroquinoxalin-2(lH)-ylidene)-2-cyanoacetate (1 eq), piperazine (3 eq) and DIPEA (3 eq) in methanol (0.1M) was stirred at 120C in a microwave for 90 minutes or until completion. The solution was cooled down, diluted in water/DCM followed by extraction with DCM. The combined organic layers were dried over MgS04, filtered, concentrated and purified by column chromatography on silica gel (0 to 100% AcOEt in hexanes) or by reverse phase C18 (5 to 100% CH3CN 0.1% TFA in water 0.1% TFA) to furnish (Z)-2-ethylbutyl 2-cyano-2-(3-(piperazin-l-yl)quinoxalin-2(lH)-ylidene)acetate., 108229-82-9

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Patent; CORSELLO, Steven M.; GOLUB, Todd R.; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; STEFAN, Eric; HILGRAF, Robert; (158 pag.)WO2018/183936; (2018); A1;,
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7712-28-9, 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7712-28-9, In a typical reaction, AMA 2:3 (10mmol), the corresponding carboxylic acid (1mmol) and the alcohol (2ml) were mixed in the provided reaction glass tube equipped with a screw cap and magnetic agitation until a wet mixture was achieved. The reaction mixture was irradiated with microwaves (Anton Parr Monowave 300 reactor) at 120C for 10-25min. On cooling, the mixture was diluted with DCM (41mL), and filtered over celite. Then the filtrate was washed with Na2CO3 (ss) and water. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to give the ester. 4.3.6.1 Methyl 3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoate (23) (0075) Alcohol: Methanol. Reaction time: 10min. Yield: 95%. Mp: 208-209C. IR (cm-1): 1730, 1655, 1615, 1510, 1490, 1565. MS (m/z): 232.3. 1H-RMN (300MHz) delta (ppm) (DMSO-d6): 2.79 (t; J=7.01Hz; 2H; CH2); 3.06 (t; J=6.83Hz; 2H; CH2); 3.60 (s; 3H; OCH3); 7.23-7.33 (m; 2H; ArH); 7.48 (t; J=7.99Hz; 1H; ArH), 7.68 (d; J=8.40; 1H; ArH), 12.36 (s.a.; 1H; NH).13C-RMN (75MHz) delta (ppm) (DMSO-d6): 28.0 (CH2); 29.8 (CH2); 51.8 (OCH3); 115.7; 123.6; 128.6; 130.0; 131.9; 132.2; 155.0 (C=N); 160.4 (C=O); 173.4 (CO).

7712-28-9 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid 151480, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Estrin, Dario; Fabian, Lucas; Gomez, Natalia; Moglioni, Albertina; Salvatori, Melina; Taverna Porro, Marisa; Turk, Gabriela; European Journal of Medicinal Chemistry; vol. 188; (2020);,
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55687-02-0,55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pd(Ph3P)4 (28.5 mg, 0.025 mmol) was added to a degassed solution of 6- bromo-2-chloroquinoxaline (60 mg, 0.246 mmol), (lR,3S,5R)-tert-butyl 3-(6-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-benzo[d]imidazol-2-yl)-2- azabicyclo[3.1.0]hexane-2-carboxylate (1 15 mg, 0.271 mmol) and sodium bicarbonate (62.1 mg, 0.739 mmol) in dioxane (1 mL) and FLO (0.2 mL) and the mixture was stirred at 1 10 C for 2 h and then at 120 C for 2 h. The reaction was diluted with MeOH, filtered and purified by prep HPLC (H20-MeOH with lOmM NH4OAc buffer) to yield (lR,3S,5R)-tert-butyl 3-(6-(6-bromoquinoxalin-2-yl)-lH-benzo[d]imidazol-2-yl)-2- azabicyclo[3.1.0]hexane-2-carboxylate (102.2 mg, 0.202 mmol, 82 % yield) as bright yellow solid. LC-MS retention time 2.31 min; m/z 506 [M+H] . (ColumnPHENOMENEX Luna 3.0 x 50mm S 10. Solvent A = 90% water: 10% methanol: 0.1% TFA. Solvent B = 10% water:90% methanol: 0.1% TFA. Flow Rate = 4 mL/min. Start % B = 0. Final % B = 100. Gradient Time = 3 min. Wavelength = 220).

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen; WO2011/59850; (2011); A1;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50998-17-9, A solution containing 6-bromo-quinoxaline (417 mg, 2.0 mmol), 4-(4 ,4,5,5- tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert- butyl ester (600 mg, 1.94 mmol), tetrakis [triphenylphosphine] palladium (108 mg, 0.1 mmol) and sodium carbonate (2 M solution, 3 ml_) in 5 ml_ of dioxane/ethanol/water (7:3:1 ) was heated at 160 C using microwave reactor for 15 minutes. After the reaction, ethylacetate was added and the mixture was filtered, washed with water. After concentration under vacuum, the product was purified using column chromatography (5% methanol in dichloromethane)

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING CORPORATION; WO2008/153858; (2008); A1;,
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2379-60-4, 2 3-Dichloro-6-nitroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1 Preparation of 7-Nitro-1,4-dithiino(2,3-b)quinoxaline-2,3-dicarbonitrile To a solution of 2,3-dichloro-6-nitroquinoxaline (1.0 g, 0.0041 mol) in dimethylformamide (20 mL) is added, in several portions, disodium-Z-1,2-dicyano-1,2-ethylenedithiolate (1.1 g, 0.0045 mol). The resulting solution is stirred overnight at room temperature. Water (100 mL) is slowly added to the reaction mixture, dropwise, with stirring. The resulting solid is isolated by filtration, washed with water and dried, giving a dark purple powder. The recovered material weighs 0.92 g and has a melting point of 222 to 225 C. A calculated overall yield of 72 percent is achieved. The structure identity is confirmed by proton nuclear magnetic resonance spectroscopy (1 H), carbon nuclear magnetic resonance spectroscopy (NMR), infrared spectroscopy (IR) and mass spectrometry (MS).

2379-60-4, 2379-60-4 2 3-Dichloro-6-nitroquinoxaline 689090, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; The Dow Chemical Company; US5200409; (1993); A;,
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55687-34-8, 6-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-34-8, To a stirred solution of the compound obtained from Preparation 29 (2 g, 8.89 mmol) in phosphorus oxychloride (15 mL), was added DMF (1 mL). The mixture was stirred at 120C for 1.5 hours then allowed to cool to room temperature. The dark solution was concentrated in vacuo and cautiously quenched with crushed ice. The aqueous suspension was neutralised with 10% potassium carbonate solution and extracted with DCM (2 x 30 mL). The combined organic phases were dried (Na2SO4), filtered and concentrated to give 1.94 g of the title compound as a brown solid.1H-NMR (400 MHz, DMSOd6): delta= 9.02(1 H, s), 8.40(1 H, d), 8.06(1 H, dd), 7.98(1 H, d). LCMS (run time = 2min): R4 = 1.69 min; m/z 243; 245 [M+H]+

The synthetic route of 55687-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER LIMITED; MILBANK, Jared Bruce John; PRYDE, David Cameron; TRAN, Thien Duc; WO2011/4276; (2011); A1;,
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