Tag: M.W:200-300

82031-32-1, 7-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7-Bromoquinoxalin-2(lH)-one (313.1 mg, 1.391 mmol) was dissolved in 0.15M DMF (9.2 mL) and treated with potassium carbonate (288.4 mg, 2.087 mmol) and iodomethane (95.5 mu,, 1.530 mmol). The reaction mixture was stirred at ambient temperature for 30 minutes. The reaction mixture was then diluted with water and extracted with EtOAc (2 X). The organics were washed with water (3 X) and brine (1 X), dried over Na2S04, filtered and concentrated. Biotage chromatography (hexanes/EtOAc) provided 7- bromo-l-methylquinoxalin-2(lH)-one (87.6 mg, 0.366 mmol, 26.3% yield). 1H NMR (400 MHz, (CD3)2SO) delta = 8.257 (s, 1H), 7.824 (s, 1H), 7.768-7.746 (d, 1H), 7.569-7.543 (dd, 1H), 3.591 (s, 3H)., 82031-32-1

As the paragraph descriping shows that 82031-32-1 is playing an increasingly important role.

Reference£º
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen; MATHIEU, Simon; MORENO, David; REN, Li; RUDOLPH, Joachim; WENGLOWSKY, Steven Mark; WO2012/118492; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

A 25-mL round bottom flask equipped with a magnetic stirrer,a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline(100 mg, 0.48 mmol), 4-Fluorophenylboronic acid (80 mg, 0.57 mmol), water/dioxane(1.0 mL/4.0 ml), K2CO3 (132 mg, 0.96 mmol). The resulting solution was degassed for 15min, then Pd(PPh3)4 (27mg, 0.024 mmol) was added. Thereaction mixture was warmed to 100 oC and stirred for 1 h. After cooled to room temperature, thereaction mixture was diluted with EtOAc and washed with saturated NaHCO3,brine, dried over Na2SO4. The organic layer wasconcentrated in rotavapor and purified on silica gel. Elution with EtOAc/hexanes solvent systemafforded the desired compound (40 mg, 38% yield). 1H NMR (400 MHz, CDCl3)delta 9.34 (s, 1H), 8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25(m, 1H).

36856-91-4, 36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Parhi, Ajit K.; Zhang, Yongzheng; Saionz, Kurt W.; Pradhan, Padmanava; Kaul, Malvika; Trivedi, Kalkal; Pilch, Daniel S.; Lavoie, Edmond J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4968 – 4974;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39267-04-4,2,3-Dichloro-6-methoxyquinoxaline,as a common compound, the synthetic route is as follows.

Example B 2,3-Dicyano-6-methoxyquinoxaline A mixture of 31.1 g of 2,3-dichloro-6-methoxyquinoxaline, 14.7 g of sodium cyanide and 2.79 g of benzyltrimethylammonium chloride is stirred in 210 ml of DMSO at room temperature for 48 hours. With intensive stirring the reaction mixture is poured onto 520 ml of ice-water, stirred for an hour, and filtered with suction, and the solid product is washed with water. Drying at 40 C. gives 23.8 g (83% of theory) of pale gray crystals with the following formula MS (m/e): 211 [M+H]+, 233 [M+Na]+ H NMR (DMSO): 8.21 (d, 1H), 7.83 (dd, 1H), 7.68 (d, 1H), 4.02 (s, 3H), 39267-04-4

The synthetic route of 39267-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Heckmann, Heino; Metz, Hans Joachim; US2007/264600; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25983-13-5,6,7-Dichloroquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.

Example 29 Preparation of 1-amino-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione The procedure of Wallace, R. G., Org. Prep. Proc. Int. 14:269 (1982) was adapted. To a stirred suspension of 6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione (189 mg, 0.82 mMol) in distilled water (15 mL) at 60 C. was added NaOH (335 mg, 8.37 mMol). After 30 min. the resulting solution was treated portionwise over 10 min. with hydroxylamino-o-sulphonic acid (111 mg, 0.98 mMol, Aldrich). Reaction was carried out at 60 C. A white precipitate came out after 10 min. The mixture was stirred at 25 C. for 8 h, it was collected by filtration at 50 C., affording 180 mg (90%) of crude 1-amino-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione, as a white amorphous solid (ratio of starting material to product=10:90 by 1 H, NMR, D2 O). Yield is 81%., 25983-13-5

25983-13-5 6,7-Dichloroquinoxaline-2,3(1H,4H)-dione 1845, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California; US5514680; (1996); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, Step 2: 6-(5,5-Dimcthyl-l,3,2-dioxaborinan-2-yl)quinoxalinc (E2)A mixture of 6-bromoquinoxaline (1.0 eq.), bis-(neopentylglycolato)diborane (1.1 eq.), KOAc (3.0 eq.) and Pd(dppf)Cl2 (0.05 eq.) in 1,4-dioxane was degassed with a stream of Ar for 10 minutes and then heated at 11O0C for 4 hrs. The reaction mixture was concentrated and the residue used in the next step without further purification. MS (ES) Ci3H5BN2O2 requires: 242, found: 175 (M-[C5Hi0] +H+).

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA; WO2007/93827; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55686-94-7,2-Chloro-7-nitroquinoxaline,as a common compound, the synthetic route is as follows.

55686-94-7, 20 mL of triethylamine (3 eq.) and 6.8 mL ofp-methoxybenzylamine (1.05 eq.) were added to a solutionof 2-chloro-7-nitroquinoxaline (4) (10.13 g, 48 mmol) inethanol (160 mL). The reaction mixture was refluxed for3 h. The solution was evaporated and the solids were filteredand washed with water to obtain an orange colored solid(13.94 g). Yield 93%; mp 171-173 C (lit. 167-169 C);13ATR/FTIR nu / cm-1 3389, 3077, 2928, 1615, 1538, 1509,1338, 741; 1H NMR (200 MHz, DMSO-d6) delta 8.50 (t, 2H,J 6.0, NH and H3), 8.27 (d, 1H, J 2.0, H8), 8.05 (dd, 1H,J 2.0, 9.0, H6), 7.96 (d, 1H, J 8.0, H5), 7.36 (d, 2H, J 8.0,H3?), 6.91 (d, 2H, J 8.0, H4?), 4.56 (d, 2H, J 6.0, CH2),3.73 (s, 3H, OCH3). 13C NMR (50 MHz, DMSO-d6)delta 158.4, 152.8, 147.5, 143.6, 141.4, 139.3, 130.4, 129.9,129.2, 120.9, 116.8, 113.8, 55.1, 43.3; DEPT-135 (50 MHz,DMSO-d6) delta 143.6, 129.9, 129.2, 120.9, 116.8, 113.8,55.1, 43.3; ESI-MS 309.3; HPLC at 230 nm 96.7% andat 254 nm 100%.

The synthetic route of 55686-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Do Amaral, Daniel N.; De Sa Alves, Fernando R.; Barreiro, Eliezer J.; Laufer, Stefan A.; Lima, Lidia M.; Journal of the Brazilian Chemical Society; vol. 28; 10; (2017); p. 1874 – 1878;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 11a (108 mg, 499 mumol), 6-bromoquinoxaline (157 mg, 751 mumol), Bu4NOAc (302 mg, 1.00 mmol) and Pd(OAc)2 (17 mg, 75.7 mumol) in NMP (1 mL). The reaction mixture was stirred for 4 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure, diluted with water and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12a (31.8 mg, 19%) as a yellow solid. TLC: Rf 0.28 (1:1 hexane/EtOAc). mp: 78.6-80.6 oC. 1H-NMR (400 MHz, CDCl3) delta 8.89 (AB quartet, 2H, J = 2.0 Hz), 8.08 (d, 1H, J = 8.0 Hz), 8.07 (s, 1H), 7.72 (t, 1H, J = 8.0 Hz), 7.63 (dd, 1H, J = 8.0 Hz, J = 2.0 Hz), 7.60 (d, 1H, J = 8.0 Hz), 7.12 (d, 1H, J = 8.0 Hz), 2.80 (t, 2H, J = 8.0 Hz), 2.19 (s, 3H), 1.74 (quintet , 2H, J = 8.0 Hz), 1.36 (sextet, 2H, J = 8.0 Hz), 0.88 (t, 3H, J = 8.0 Hz). 13C-NMR (100 MHz, CDCl3) delta 158.0, 149.1, 147.4, 145.6, 145.5, 142.6, 142.5, 138.9, 132.5, 132.0, 130.9, 130.2, 129.0, 123.3, 115.0, 31.6, 24.6, 23.6, 22.4, 13.7. HRMS (ESI) calcd. for C20H21N6 (M+H): 345.1822; found 345.1824., 50998-17-9

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In N2in the gas purification system, the 5,8- […][…] soluble in toluene solvent, and by adding 4 – (diphenyl amino) phenyl boronic acid (1.1 equivalent). The K2CO3 (4.4 equiv) dissolved in distilled water in and added to the mixed solution. By adding tetrahydrofuran solvent, and by adding palladium (0.05 equiv). The mixture at 80 C and the temperature of the refluxing under stirring. After the reaction is finished, by ethyl acetate extraction mixture. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the remaining organic solvent. The material through the use of methylene chloride and hexane to carry out wet refining column chromatography, thereby obtaining compound “m”. (Yield: 43%), 148231-12-3

148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

887590-25-2,887590-25-2, tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 3,4-dihydro-2H-quinoxaline-1-carboxylate (17 g, 72.6 mmol) in MeCN (150 mL) was added N-bromosuccinimide (12.3 g, 68.9 minol) by portionwise at 0 C. The mixture was stirred at 0 C for I h. The reaction was quenched with water (200 mE), extracted with EtOAc (200 mE x 3). The combined organic layers were dried over anhydrousNa2SO4, filtered and concentrated in vacuo. The crude residue was purified by silica gel chromatography (petroleum ether / EtOAc 20: 1 to 4: 1) to give the title compound (14.0 g, 62%) as a light yellow solid. ?H NMR (400 MHz, DMSO-d6) 8 7.50 (s, iH), 6.95 – 6.92 (m, 1H), 6.52 – 6.50 (m, IH), 6.29 (s, 1H), 3.58 – 3.56 (m, 2H), 3.24 – 3.23 (m, 2H), 1.45 (s, 9H).

887590-25-2 tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate 16740533, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ROMERO, F. Anthony; MAGNUSON, Steven; PASTOR, Richard; TSUI, Vickie Hsiao-Wei; MURRAY, Jeremy; CRAWFORD, Terry; ALBRECHT, Brian, K.; COTE, Alexandre; TAYLOR, Alexander, M.; LAI, Kwong Wah; CHEN, Kevin, X.; BRONNER, Sarah; ADLER, Marc; EGEN, Jackson; LIAO, Jiangpeng; WANG, Fei; CYR, Patrick; ZHU, Bing-Yan; KAUDER, Steven; (0 pag.)WO2016/86200; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In N2in the gas purification system, the use of a compound “d” (0.3mol), 5,8-di bromo-Oxoquinoxaline (0.15mol), Pd (OAc)2(6.11mmol), P(t-Bu)3(50 wt %, 15 . 28mmol) sodium and tertiary butyl alcohol (0.61mol) is added to the toluene solvent and stirring. In the solution 120 C and the temperature of the refluxing under stirring 12 hours. After the completion of reaction, the solution is cooled to the room temperature and water and ethyl acetate extraction. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the solvent. The material through the use of hexane and ethyl acetate to carry out wet refining column chromatography, so as to obtain compound 22. (Yield: 79%), 148231-12-3

As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider