Tag: M.W:200-300

50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,50998-17-9

To a solution of 11d (30 mg, 101 mumol), 6-bromoquinoxaline (31.4 mg, 150 mumol), Bu4NOAc (60.2 mg, 200 mol) and Pd(OAc)2 (3.37 mg, 15 mol) in NMP (0.5 mL). The reaction mixture was stirred for 9 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure, diluted with water and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12c (5.1 mg, 12%) as a yellow solid. TLC: Rf 0.25 (1:1 hexane/EtOAc). mp: 157-159 oC. 1H-NMR (400 MHz, CDCl3) delta 8.89 (d, 1H, J = 1.6 Hz), 8.85 (d, 1H, J = 1.6 Hz), 8.13 (d, 1H, J = 8.8 Hz), 8.08 (d, 1H, J = 2.0 Hz), 7.80 (dd, 1H, J = 8.8 Hz, J = 2.0 Hz), 7.73 (t, 1H, J = 8.0 Hz), 7.63 (d, 1H, J = 8.0 Hz), 7.12 (d, 1H, J = 8.0 Hz), 6.75 (d, 1H, J = 2.0 Hz), 6.40 (t, 1H, J = 2.0 Hz) 3.64 (s, 6H), 2.18 (s, 3H). 13C-NMR (100 MHz, CDCl3) delta 161.0, 158.3, 149.0, 146.0, 145.9, 145.8, 143.0, 142.6, 139.1, 132.7, 132.4, 132.1, 131.6, 131.0, 129.5, 123.7, 115.7, 105.7, 101.1, 55.4, 23.8.HRMS (ESI) calcd. for C24H21N6O2 (M+H): 425.1721; found 425.1724.

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
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55687-34-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-34-8,6-Bromoquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

Example 16 1-(6-Bromoquinoxalin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol (38)To 6-bromoquinoxalin-2(1H)-one (250 mg, 1.11 mmol) was added POBr3 (500 mg, 2.61 mmol) at RT. The reaction mixture was gradually heated to 130 C. and stirred for 2 h. After completion of reaction (by TLC), the reaction mixture was cooled to 0 C., neutralized with satd NaHCO3 solution (50 mL) and extracted with EtOAc (2¡Á50 mL). The combined organic extracts were washed with H2O (50 mL) and brine (50 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude material. Purification by silica gel column chromatography (eluting with 10% EtOAc/hexane) afforded compound AI (160 mg, 0.55 mmol, 50%) as an off-white solid. 1H NMR (200 MHz, CDCl3): delta 8.84 (s, 1H), 8.30 (d, J=9.0 Hz, 1H), 7.96-7.82 (m, 2H).

As the paragraph descriping shows that 55687-34-8 is playing an increasingly important role.

Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; US2012/329802; (2012); A1;,
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76982-23-5, 5-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76982-23-5, General procedure: To a magnetically stirred solution of quinoxaline (1) (2.60g, 20.0mmol) in chloroform (150mL) was added m-CPBA (13.45g, 77%, 60.0mmol) portionwise at 0C. The reaction mixture was stirred for 48hat room temperature. The mixture was diluted with a solution of sodium hydroxide (10%, 20mL) and extracted with methylene chloride (3¡Á50mL). The combined organic layers were washed with saturated brine (2¡Á30mL), water, dried over Na2SO4, and filtered. The solvent was removed in vacuo. Quinoxaline-1,4-dioxide (26),20f,28 (3.20g, 99%) was obtained as a pure product (Yellow solid, mp 241-242C, lit.20f mp 241-243C

As the paragraph descriping shows that 76982-23-5 is playing an increasingly important role.

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Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 13A 1-Quinoxalin-6-yl-ethanone A solution of 6-bromo-quinoxaline (261 mg, 1.25 mmol), 1-ethoxyvinyltri-n-butyltin (0.47 mL, 1.4 mmol), palladium(II) acetate (16 mg) and tri-t-butylphosphonium tetrafluoroborate (41 mg) in anhydrous DMF (4 mL) under a nitrogen atmosphere was heated at 120 C. for 1 hr. The reaction mixture was cooled to ambient temperature and partitioned between ethyl acetate (25 mL) and H2O (10 mL). The organic extraction was washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was chromatographed on silica gel eluding with ethyl acetate:hexanes (1:1) to provide 110 mg of the title compound. 1H NMR (300 MHz, CDCl3) delta 2.79 (s, 3H), 8.18 (d, J=9 Hz, 1H), 8.36 (dd, J=9 Hz, J=3 Hz, 1H), 8.70 (d, J=3 Hz, 1H), 8.95 (s, 2H); MS (DCl/NH3) m/z 173 (M+H)+., 50998-17-9

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-Yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.; US2005/272736; (2005); A1;,
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212327-10-1, 7-Bromo-2-methoxyquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0211] To a solution of 7-bromo-2-methoxyquinoxaline (26.7 g, 0.11 mol, 1.0 eq.) in DMF (1100 mL) were added TEA (77.7 mL, 0.56 mol, 5.0 eq.), Et3SiH (71.2 mL, 0.45 mol, 4.0 eq.) and Pd(dppf)Cl2CH2Cl2 (4.56 g, 5.6 mmol, 0.05 eq.). The resulting mixture was stirred at 90 C in an autoclave for 12 h under CO (1 MPa), then cooled and concentrated. The resulting residue was purified via flash column chromatography (EA/PE=l/4, v/v) to afford 3-methoxyquinoxaline-6-carbaldehyde as a white solid (8.5 g, 40.5%yield).

212327-10-1, 212327-10-1 7-Bromo-2-methoxyquinoxaline 1237168, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2014/75077; (2014); A1;,
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55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-02-0, Preparation of tert-butyl 2-(4-(6-bromoquinoxalin-2-yl)phenyl)-2-oxoethylcarbamate A suspension of tert-butyl 2-oxo-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate (1.5 g, 4.15 mmol, Eq: 1.00), 6-bromo-2-chloroquinoxaline (1.01 g, 4.15 mmol, Eq: 1.00), cesium carbonate (2.71 g, 8.3 mmol, Eq: 2) and tetrakis(triphenylphosphine)palladium (0) (480 mg, 415 mumol, Eq: 0.1) in Dioxane (20 ml) and Water (2 ml) was purged with nitrogen for 10 min. then r*n. Mixture was heated at 80 C. for 16 hrs. Solvent removed in vacuo, the black residue filtered through a pad of Celite, washed with EtOAc, concentrated, triturated with ether, light yellow solid filtered, dried to obtain tert-butyl 2-(4-(6-bromoquinoxalin-2-yl)phenyl)-2-oxoethylcarbamate (1.7 g, 3.84 mmol, 92.6% yield) as a light yellow powder. LC/MS (M++H)=443

As the paragraph descriping shows that 55687-02-0 is playing an increasingly important role.

Reference£º
Patent; Alam, Muzaffar; Berthel, Steven Joseph; Brinkman, John A.; Hawley, Ronald Charles; Li, Hongju; Palmer, Wylie Solang; Pietranico-Cole, Sherrie; Sarabu, Ramakanth; Smith, Mark; So, Sung-Sau; Yi, Lin; Zhai, Yansheng; Zhang, Qiang; Zhao, Shu-Hai; US2012/230951; (2012); A1;,
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98416-72-9, 6-Bromo-2-chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Aminophenol (0.01 mol) was dissolved in a mixture of acetonitrile(50 mL) and DMF (5 mL) containing anhydrous potassium carbonate(2.0 g). The mixture was refluxed for 1 h, then (5, 0.01 mol)was added and the mixture was further refluxed for 6 h (monitoredby TLC). After completion of the reaction, the mixture was filteredand the excess of acetonitrile was evaporated under reduced pressureand crystallized from ethanol to give the correspondingcompounds, 98416-72-9

As the paragraph descriping shows that 98416-72-9 is playing an increasingly important role.

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Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50998-17-9, Description 137; 6-Quinoxalin-6-vlpvrimidin-4-amine; 6-Bromoquinoxaline (210 mg, 1.44 mmol), potassium acetate (141 mg, 1.44 mmol), bis (pinacolato) diboron (383 mg, 1.51 mmol) and [1, 1′- bis (diphenylphosphino) ferrocene] palladium (II) chloride (52 mg, 0.072 mmol) were suspended in dioxane (10 ml) and heated to 100C for 16 hours. 4-Amino-6- chloropyrimidine [WO-A-0245652] (186 mg, 1.44 mmol), [l, 1′- bis (diphenylphosphino) ferrocene]-palladium (II) chloride (52 mg, 0.072 mmol) and 2M Na2CO3 (aq) (2ml) were added and the mixture was heated at 100 oC for a further 16 hours. The mixture was partitioned between EtOAc and water, the aqueous phase was extracted with EtOAc, the combined organic phases were washed (brine), dried (sodium sulfate) and concentrated under reduced pressure. The residue was triturated with EtOAc to give a white solid, which was used in the next step without purification (170 mg).

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2005/47279; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, Example 13l-ethyl-3-(5-(quinoxalin-6-yl)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-2-yl)ureaA reaction mixture of l-ethyl-3-(5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-4-(4- (trifluoromethyl)thiazol-2-yl)pyridin-2-yl)urea (Intermediate 12, 100 mg, 0.23 mmol), 6- bromoquinoxaline (43.0 mg, 0.21 mmol),Tetrakis (23.75 mg, 0.02 mmol), and cesium carbonate (73.7 mg, 0.23 mmol) in dioxane and water was prepared. The reaction mixture was degassed with nitrogen for 15 minutes and then heated to 100 0C for 1 h. The reaction mixture was partitioned between methylene chloride and water. The organic layer was washed with saturated sodium chloride, dried over sodium sulfate, filtered, and concentrated under reduced pressure. Purification by flash column chromatogrpahy (silica, 15:1 methylene chloride/methanol) gave 44 mg of desired product.MS (ESP): 445 (M+ 1) for C20H15F3N6OS.1H NMR (300 MHz, DMSO-J6): 1.12 (t, J = 7 Hz, 3H), 3.24 (m, 2H), 7.23 (m, IH), 7.43 (m, IH), 8.04 (m, IH), 8.21 (m, IH), 8.36 (m, IH), 8.55 (m, IH), 9.02 (br s, 2H), 9.36 (s, IH), 9.52 (s, IH).

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BIST, Shanta; EAKIN, Ann; SHERER, Brian; ZHAO, Shannon; WO2011/24004; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25983-13-5,6,7-Dichloroquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.

General procedure: 2,2?-Bipyridine (0.071 g, 0.455 mmol) was added to a solution containing 0.100 g (0.454 mmol) of Cr(CO)6 in 50 mL of THF. The mixture was refluxed for 2 h with continuous stirring. The resulting orange colored solution was cooled down to room temperature. DCQX (0.104 g, 0.450 mmol) was dissolved in 20 mL of EtOH and slowly added to the reaction mixture. The contents were refluxed for 18 h with continuous stirring, and during this time the brown solid product separated from solution. The solid was isolated, washed with 15 mL THF/EtOH (1:1) and dried in vacuum. A concentrated solution of the product in DMSO/EtOH (3:1) was allowed to evaporate slowly for 2 weeks, which resulted in a reddish-brown powder. Washing the powdery solid with EtOH followed by diethyl ether and then drying overnight in vacuum resulted in 0.13 g (59.6% yield) of the pure product (one brown spot in a TLC test). Attempts to obtain crystals suitable for X-ray crystallography were unsuccessful due to the limited solubility of the synthesized complex in most common solvents. Anal. Calc. for C40H34Cl4Cr2N8O6 (Mr = 968.55): C, 49.60; H, 3.54; Cl, 14.64; N, 11.57. Found: C, 49.53; H, 3.52; Cl, 14.70; N, 11.62%. Effective magnetic moment at 298 K, mueff (BM): 2.955., 25983-13-5

The synthetic route of 25983-13-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Attia, Attia S.; Abdel Aziz, Ayman A.; Alfallous, Khalifa A.; El-Shahat; Polyhedron; vol. 51; 1; (2013); p. 243 – 254;,
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