Tag: M.W:200-300

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,49679-45-0

General procedure: Method A: a solution of compound 3 (1.11 g, 4.70 mmol), 3- aminophenol (622 mg, 5.70 mmol) and p-TSA, as a catalyst, in absolute ethanol (40 mL) was refluxed for 110 h. Ethanol was then evaporated under reduced pressure, and the resulting residue was purified by silica column chromatography using cyclohexane with ethyl acetate gradient (0e50%) as eluent to give the desired compound 4a (1.0 g, 69%) as a red powder.

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Oyallon, Bruno; Brachet-Botineau, Marie; Loge, Cedric; Bonnet, Pascal; Souab, Mohamed; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Berthelot, Pascal; Gouilleux, Fabrice; Viaud-Massuard, Marie-Claude; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 101 – 109;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1910-90-3,6-Bromoquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.

EXAMPLE 1 6-Bromo-2,3-dihydroxy-7-nitroquinoxaline To a solution of 0.5 g (2.1 mmol) of 6-bromo-2,3-dihydroxy quinoxaline in 5 ml of concentrated sulfuric acid is added at 0 C. 210 mg (2.1 mmol) KNO3. The solution is stirred at 0 C. for 30 min. and at 24 C. for 3 h. The reaction mixture is poured into ice-water giving 5 g precipitate. The crude product is dissolved in 30 ml of hot 2N NaOH. 4N HCl is added ajusting pH to 2 giving 0.4 g (67%) of 6-bromo-2,3-dihydroxy-7-nitro-quinoxaline, m.p. >300 C. NMR: two singlets (ppm 7.3 and 7.7 downfield from TMS).

1910-90-3, The synthetic route of 1910-90-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; A/S Ferrosan; US4812458; (1989); A;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, 11k (100 mg, 400 mol), 6-bromoquinoxaline (125 mg, 600 mumol), Bu4NOAc (241 mg, 799 mol) and Pd(OAc)2 (4.5 mg, 20.0 mol) were dissolved in NMP (1.6 mL ). The reaction mixture was stirred at 100 oC for 22 h and cooled to room temperature. The mixture was quenched with water (10 ml) treated with saturated aqueous NaHCO3 solution (3 ml), and extracted with EtOAc (3 ¡Á 30 mL). The combined organic extracts were dried (MgSO4), filtered, and concentrated by rotary evaporation. The residue was purified by column chromatography (1:1.5 hexane/EtOAc) to afford the compound 12k (33.4 mg, 22%) as a yellow solid. TLC: Rf 0.33 (1:1 hexane/EtOAc). mp: 112.5114.5 oC. 1H-NMR (400 MHz; CDCl3) delta 8.89 (d, 1H, J = 1.6 Hz), 8.88 (d, 1H, J = 1.6 Hz), 8.04 (d, 1H, J = 8.8 Hz), 8.01 (d, 1H, J = 1.6 Hz), 7.72 (t, 1H, J = 7.6 Hz), 7.62 (d, 1H, J = 7.6 Hz), 7.55 (dd, 1H, J = 8.8 Hz, J = 1.6 Hz), 7.26-7.14 (m, 5H), 7.11 (d, 1H, J = 7.6 Hz), 4.17 (s, 2H), 2.17 (s, 3H). 13C-NMR (100 MHz; CDCl3) delta 158.3, 149.2, 146.2, 145.9, 145.8, 142.8, 142.7, 139.2, 138.9, 133.4, 132.2, 130.7, 130.6, 129.2, 128.8, 128.7, 126.6, 123.6, 115.2, 31.4, 23.8. HRMS (ESI) calcd. for C23H19N6 (M+H): 379.1666; found 379.1662.

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

55687-02-0, To solution of 6-bromo-2-chloro-quinoxaline (0.7 g, 1 eq, 2.87 mmol) in THF (6 mL) was added a solution of methyl amine in THF (3 mL) at room temperature. The mixture was stirred at room temperature for 2 h. After completion of the reaction, the volatiles were removed under vacuum and water (20 mL) was added to reaction mixture. The aqueous layer was extracted with ethyl acetate (15 mL x 3). The organic layer was washed with water (20 mL) and brine (20 mL) and then dried over Na2SO4. The organic layer was concentrated under vacuum to afford the crude product.For final purification, column chromatography was used on neutral silica gel of 60-120 mesh size employing a gradient of 3-5% ethyl acetate in hexane to elute the title compound (0.6g, 87%).

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
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108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 (2.78 g, 0.01 mol) in DMF(50 mL), 2-aminopyridine (0.94 g, 0.01 mol) was added. The reaction mixture was refluxed for 17 h. After completion of the reaction, the reaction mixture was poured onto crushed ice with stirring. Then, the precipitate that formed was filtered, washed with water, dried and crystallized from petroleum ether(80-100C) to give the product. Yield: 40%; (yellow-brown powder): m.p.157-159 O C; IR (KBr, cm -1 ): 1610 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 7.27-7.77 (m, 7H, Ar-H). 13 CNMR (DMSO-d 6 , delta , ppm): 121.79-141.44 (10Ar-C),151.27, 151.56, 151.91 (3C=N). MS (m/z), 78 (M + -C 8 H 3 BrN 3 ; 100%), 298 (M + ; 46%), 299 (M + + 1;10%), 300 (M + + 2; 45%). Analysis: calcd. forC 13 H 7 BrN 4 (299.13): C, 52.20; H, 2.36; N, 18.73%;found: C, 52.43; H, 2.52; N, 18.92%., 108229-82-9

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9

General procedure: Method A: To a solution of compound 1 (2.78g, 0.01 mol) in DMF (50 mL), an appropriate cyclic secondary amine namely, piperidine or morpholine(0.01 mol) was added. The reaction mixture was refluxed for 10-14 h. After completion of the reaction, the reaction mixture was poured onto crushedice with stirring. The formed precipitate was filtered, dried and crystallized from petroleum ether(80-100C) to give the corresponding compounds.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

A 25-mE round bottom flask equipped with a magneticstirrer, a condenser and a nitrogen inoutlet adapter was charged with 2-bromoquinoxaline (13 mg, 0.063 mmol), boronate ester 6b (25 mg, 0.063 mmol), water/dioxane (1.0 mE/4.0 ml), K2C03 (17 mg, 0.126 mmol). The resulting solution was degassed for 15 mm, then Pd(PPh3)4 (5 mg)was added. The reaction mixture was warmed to 1000 C. and stirred for 1 h. After cooled to room temperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHCO3, brine, dried over Na2SO4. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with 10% EtOAc/hexanes solvent system afforded the desired compound (15 mg, 60% yield).1H NMR (300 MHz, CDCl3) oe 9.46 (s, 1H), 8.83 (s, 1H), 8.69 (m, 1H), 8.46 (s, 1H), 8.21 (m, 2H), 7.86 (m, 2H), 7.72 (d, J=12.0 Hz, 2H), 7.58 (d, J=12.0 Hz, 2H), 4.05 (s, 3H), 1.42 (s, 9H)., 36856-91-4

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Rutgers, The State University of New Jersey; LaVoie, Edmond J.; Parhi, Ajit; Pilch, Daniel S.; Kaul, Malvika; (36 pag.)US9822108; (2017); B2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

55687-02-0,55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 40 (420 mg, 1.73 mmol) in ethanol (5 ml) was added excess hydrazine monohydrate (1.5 ml), and the resulting mixture was stirred at reflux for 16 h. The reaction mixture was concentrated under reduced pressure, and the solid residue was washed with diethyl ether, and dried in vacuo to give the title compound 41 (80%) .

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BANDYOPADHYAY, Anish; SARANGTHEM, Robindro; BARAWKAR, Dinesh; BONAGIRI, Rajesh; KHOSE, Goraksha; SHINDE, Shailesh; (226 pag.)WO2016/199943; (2016); A1;,
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1233318-23-4, Methyl 2-(quinoxalin-6-yl)acetate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Trimethylsilyldiazomethane [2.0M in hexanes] (0.08?xL) was added dropwise to a solution of quinoxalin-6-yl-acetic acid (0.030g, 0.159mmol) in toluene/methanol [8/1] (0.5mL) and stirred until the bubbling stopped. The reaction was then evaporated and the crude product was purified via silica gel column chromatography in hexane: ethyl acetate (1:1) to give 0.013g of quinoxaJin-6-yl-acetic acid methyl ester. This was added to a solution of hydrazine (O.lOinL) in methanol and stirred at room temperature overnight. The reaction mixture was evaporated in vacuo to give 0.019g of quinoxalin-6-yl-acetic acid hydrazide. 1H NMR (400 MHz, DMSO-d6) 8 9.77 (bs, IH), 9.35 (m, 2H), 8.46 (d, IH, J=8.8Hz), 8.39 (m, IH), 8.19 (dd, IH, J=2.0, 8.8Hz), 4.68 (bs, 2H), 4.07 (s, 2H)., 1233318-23-4

1233318-23-4 Methyl 2-(quinoxalin-6-yl)acetate 67428601, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/75567; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49679-45-0,Ethyl 3-chloroquinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

(1) To a solution of ethyl 3-chloroquinoxaline-2-carboxylate prepared by a method recited in J. Chem. Soc. 1945, 622; 12.3 g, 52.0 mmol and triethylamine (8.70 mL, 62.4 mmol) in N,N-dimethylformamide (52 mL) was added aqueous dimethylamine (50%, 6.60 mL, 62.7 mmol) at room temperature. After being stirred for 3 hour at room temperature, the reaction mixture was poured into water (500 mL), and the mixture was extracted with ethyl acetate (2000 mL). The organic layer was washed with water, dried over sodium sulfate, filtrated and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate = 4:1) to give ethyl 3-(dimethylamino)quinoxaline-2-carboxylate as a pale yellow oil (12.6 g, 99%). MS (APCI): m/z 246 (M+H).

49679-45-0, The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; MORIMOTO, Hiroshi; SAKAMOTO, Toshiaki; HIMIYAMA, Toshiyuki; KAWANISHI, Eiji; MATSUMURA, Takehiko; WO2010/30027; (2010); A1;,
Quinoxaline – Wikipedia
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