With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.
General procedure: Method A: To a solution of compound 1 (2.78g, 0.01 mol) in DMF (50 mL), an appropriate cyclic secondary amine namely, piperidine or morpholine(0.01 mol) was added. The reaction mixture was refluxed for 10-14 h. After completion of the reaction, the reaction mixture was poured onto crushedice with stirring. The formed precipitate was filtered, dried and crystallized from petroleum ether(80-100C) to give the corresponding compounds., 108229-82-9
The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider