New learning discoveries about 879-65-2

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, EXAMPLE 53; 2-[fOuinoxaline-2-carbonyl)-aminol-indan-2-carboxylic acid ethyl ester (53):To a solution of quinoxaline-5-carboxylic acid (400mg, 2.3mmol), 2-amino-indan-2- carboxylic acid ethyl ester (471mg, 2.3mmol), HATU (1.3g, 3.45mmol) in anhydrous DMF (15mL) is added DIPEA (570muL, 3.45mmol). The resulting solution is stirred at RT overnight.75 After the removal of DMF in vacuo, the residue is dissolved in EtOAc (5OmL) and washed with water (I x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (115g silica gel, gradient elution: 5-40% EtOAc in heptane) to give a pure product (56) as an orange solid (605mg, 73%).1H NMR (CDCl3, 300MHz): delta 1.26(t, 3H), 3.55(d, 2H), 3.84(d, 2H), 4.28(q, 2H), 7.21-7.29(m, 4H), 7.79-7.89(m, 2H), 8.08-8.18(m, 2H), 8.46(s, IH), 9.64(s, IH) LC/MS (ES+) m/z = 361.12

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; WO2008/151211; (2008); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider