Liu, Chun-He published the artcileDesign, synthesis, and biological evaluation of novel 4-alkylamino-1-hydroxymethylimidazo[1,2-a]quinoxalines as adenosine A1 receptor antagonists, HPLC of Formula: 25983-14-6, the main research area is oxoalkylamino chloroquinoxaline heterocyclization; imidazoquinoxaline preparation amine amination; aminoimidazoquinoxaline preparation adenosine receptor ligand.
A series of 4-alkylamino-1-hydroxymethylimidazo[1,2-a]quinoxalines, e.g., I, have been synthesized and evaluated for their adenosine A1 receptor inhibitory activity in the radioligand binding assays. These compounds were tested for the inhibition percent (IP) and the affinity toward A1AR (Ki) that IP were more than 90% in the nanomolar range. 4-Cyclopentylamino-7,8-dichloro-1-hydroxymethylimidazo[1,2-a]quinoxaline (I) was the most potent compound in this series, having Ki = 7 nM, which is remarkably higher than that of IRFI-165 (Ki = 48). 1-Hydroxymethyl groups of the tricyclic heteroaromatic compounds displayed the potent affinities toward A1AR.
Bioorganic & Medicinal Chemistry published new progress about Structure-activity relationship, purinergic receptor-binding. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, HPLC of Formula: 25983-14-6.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider