Metal & Surfactant-Free oxidation of Quinoxalin-2(1H)-ones: Access to Quinoxaline-2,3-diones was written by Li, Xuan;Zang, Jiawang;Wang, Shoucai;Kang, Chen;Xu, Jiawei;Jiang, Guangbin;Ji, Fanghua. And the article was included in Tetrahedron Letters in 2022.Electric Literature of C8H5BrN2O2 This article mentions the following:
An efficient and direct metal & surfactant-free surfactant-free oxidation of quinoxalin-2(1H)-ones for the construction of 1,4-dihydroquinoxaline-2,3-diones I [R = Me, Et, Bn, etc.; R1 = H, 7-NO2, 6-OMe, etc.] was developed. A range of oxidative products are obtained with satisfactory yields (up to 99%). This practical method featured transition metal free, surfactant free, chromatog. free, mild reaction conditions, good functional group tolerance and easy scale-up synthesis. Furthermore, it provided a convenient approach for the synthesis of one kind of known inhibitor for α-glucosidase. This mechanistic study showed that this transformation was not a radical process. In the experiment, the researchers used many compounds, for example, 6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3Electric Literature of C8H5BrN2O2).
6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Electric Literature of C8H5BrN2O2
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider