With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.
A suspension of 2,3,6-trichloroquinoxaline (J. Med. Chem. 33, 2240-54,1990) (5.84 g, 25 mmol) in dry methanol (70 ml) was stirred at 50 C. while methanolic sodium methoxide (30 mmol) (prepared from 0.7 g of sodium and 70 ml of dry methanol) was added over 5 hours. After the addition was complete, heating and stirring was continued for a further 16 hours. The mixture was cooled in an ice bath, the precipitate filtered off, washed with a small amount of methanol and dried to afford 4.28 g of a mixture consisting of 2,3-dimethoxy-6-chloroquinoxaline, 2,6-dichloro-3-methoxyquinoxaline and 3,6-dichloro-2-methoxy-quinoxaline, respectively., 2958-87-4
The synthetic route of 2958-87-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Novo Nordisk A/S; US6927214; (2005); B1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider