With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.
55687-02-0, In a 10 ml seal tube, methyl (4S,7S)-6,10-dioxo-4-(5-(4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)- 1 H-imidazol-2-yl)octahydro- 1 H-pyridazino [ 1 ,2- a][l,2]diazepin-7-ylcarbamate (240 mg, 459 muiotaetaomicron?) (Intermediate 3), 6-bromo-2- chloroquinoxaline (112 mg, 459 muiotaetaomicron?) and Cs2C03 (299 mg, 917 muiotaetaomicron?) were combined with 1,4-dioxane (3.00 ml) and water (0.5 ml) to give a light brown solution. It was degased for 10 min and tetrakis(triphenylphosphine)palladium (0) (53.0 mg, 45.9 muiotaetaomicron?) was added. The reaction mixture was heated at 80 C for 16 h. It was diluted with EtOAc (6 ml) andconcentrated in vacuo. The residue was purified on a silica gel column (CH2C12, 2%, 3%, 5%, 8% and 10% MeOH/CH2Cl2 ) to afford methyl (4S,7S)-4-(5-(4-(6-bromoquinoxalin-2- yl)phenyl)- 1 H-imidazol-2-yl)-6, 10-dioxooctahydro- 1 H-pyridazino [ 1 ,2-a] [ 1 ,2]diazepin-7- ylcarbamate as a red solid (240 mg, 86.6%). ESI-LRMS m/e calcd for C28H26BrN704 [M+] 604, found 605 [M+H+].
As the paragraph descriping shows that 55687-02-0 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; BRINKMAN, John A.; LI, Hongju; SARABU, Ramakanth; SO, Sung-Sau; WO2013/53657; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider