Category: 108229-82-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 1 (2.78 g, 0.01 mol)and arylthiosemicarbazone (0.01 mol) in absolute ethanol (50 mL) was refluxed for 4-5 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried and crystallized from benzene to produce the corresponding compounds.

108229-82-9, As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

108229-82-9, Method A: To a solution of thiophenol (2.20 g,0.02 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and compound 1 (2.78 g,0.01 mol) were added. The reaction mixture washeated under reflux for 3 h. After completion of thereaction, the reaction mixture was filtered to removethe potassium carbonate, then the excess of acetoni-trile was evaporated under reduced pressure and theresidue obtained was dried and purified by a silicagel column chromatography (petroleum ether (60-80 O C)/ethyl acetate 5 : 0.1, v/v) to give the product;yield: 68%.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9

General procedure: Method A: To a solution of compound 1 (2.78g, 0.01 mol) in DMF (50 mL), an appropriate cyclic secondary amine namely, piperidine or morpholine(0.01 mol) was added. The reaction mixture was refluxed for 10-14 h. After completion of the reaction, the reaction mixture was poured onto crushedice with stirring. The formed precipitate was filtered, dried and crystallized from petroleum ether(80-100C) to give the corresponding compounds.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 (2.78 g, 0.01 mol) in DMF(50 mL), 2-aminopyridine (0.94 g, 0.01 mol) was added. The reaction mixture was refluxed for 17 h. After completion of the reaction, the reaction mixture was poured onto crushed ice with stirring. Then, the precipitate that formed was filtered, washed with water, dried and crystallized from petroleum ether(80-100C) to give the product. Yield: 40%; (yellow-brown powder): m.p.157-159 O C; IR (KBr, cm -1 ): 1610 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 7.27-7.77 (m, 7H, Ar-H). 13 CNMR (DMSO-d 6 , delta , ppm): 121.79-141.44 (10Ar-C),151.27, 151.56, 151.91 (3C=N). MS (m/z), 78 (M + -C 8 H 3 BrN 3 ; 100%), 298 (M + ; 46%), 299 (M + + 1;10%), 300 (M + + 2; 45%). Analysis: calcd. forC 13 H 7 BrN 4 (299.13): C, 52.20; H, 2.36; N, 18.73%;found: C, 52.43; H, 2.52; N, 18.92%., 108229-82-9

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of compound 1 (2.78 g, 0.01 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and an appropriate cyclic secondaryamine namely, piperidine or morpholine (0.01 mol) was added. The reaction mixture was refluxed for 4-h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the excess of acetonitrile was evaporated under reduced pressure and the residue obtained was dried and crystallized from petroleum ether (60-80C) to afford the corresponding compounds., 108229-82-9

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: Method A: To a solution of compound 1 (2.78g, 0.01 mol) in DMF (50 mL), an appropriate cyclic secondary amine namely, piperidine or morpholine(0.01 mol) was added. The reaction mixture was refluxed for 10-14 h. After completion of the reaction, the reaction mixture was poured onto crushedice with stirring. The formed precipitate was filtered, dried and crystallized from petroleum ether(80-100C) to give the corresponding compounds., 108229-82-9

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of substituted 7,8-dimethoxytetrazolo-[1,5-a]-quinazolin-5-amine 4 (0.001 mol) and 2,3-dichloroquiaxoline 2a-e (0.01 mol) in glacial acetic acid 10 mL containing 0.2 mL of DMF as a catalyst wa refluxed for 12-15 hr. after completion of the reaction (monitored by TLC), the reaction mixture was poured into water, the solid separated was filtered, washed with water, dried and purified by column chromatodraphy (2:8 CHCl3:EA) to furnish the desired compounds 5a-e.

108229-82-9, 108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Srinivas; Prasanna; Ravinder; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 53; 2; (2014); p. 238 – 242;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

To a solution of compound 1 (2.78 g, 0.01 mol) in DMF (50 mL), 4-aminophenol (2.18 g, 0.02 mol) was added. The reaction mixture was refluxed for 18h. After completion of the reaction, the reactionmixture was poured onto crushed ice with stirring. Then, the precipitate that formed was filtered, washed with water, dried and crystallized frompetroleum ether (80-100C) to give the title com-pound 5.Yield: 64%; (brown powder): m.p. 159-161 O C;IR (KBr, cm -1 ): 3423 (OH), 3162 (NH), 1617 (C=N).1 H NMR (DMSO-d 6 , delta , ppm): 7.04-8.11 (m, 11H,Ar-H), 9.03 (s, br, 2H, 2NH; exchangeable withD 2 O), 11.96 (s, br, 2H, 2OH; exchangeable withD 2 O). 13 C NMR (DMSO-d 6 , delta , ppm): 122.18-141.61(12Ar-C), 154.82, 154.94 (2C=N). MS (m/z), 422(M + ; 82%), 423 (M + + 1; 100%), 424 (M + + 2; 79%).Analysis: calcd. for C 20 H 15 BrN 4 O 2 (423.26): C,56.75; H, 3.57; N, 13.24%; found: C, 56.61; H, 3.74;N, 13.49%.

108229-82-9, As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider