Category: 1865-11-8

1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of freshly prepared saturated aqueous ammonia (20mL) and 2-quinoxalinecarboxylate (115mg, 0.612 mmol) was stirred at room temperature for 18 hours. The solution was then evaporated under reduced pressure to yield the product as an off-white solid in quantitative yield. Elemental analysis calcd (percent) for C9H7N3O (173.06): Calc. C 62.40 H 4.07 N 24.26; found: C 62.40 H 4.11 N 23.94. 1H NMR (400 MHz, d6-DMSO): δ (ppm) 9.439 (s, 1H, H5), 8.237 (dd, J1-2 = 8 Hz, J1-3 = 2 Hz, 1H, H1), 8.194 (dd, J4-3 = 8 Hz, J4-2 = 0.8 Hz, 1H, H4), 7.997 (q-br, J2/3-3/2/1/4 = 10 Hz, 2H, H2/3)., 1865-11-8

As the paragraph descriping shows that 1865-11-8 is playing an increasingly important role.

Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of freshly prepared saturated aqueous ammonia (20mL) and 2-quinoxalinecarboxylate (115mg, 0.612 mmol) was stirred at room temperature for 18 hours. The solution was then evaporated under reduced pressure to yield the product as an off-white solid in quantitative yield. Elemental analysis calcd (%) for C9H7N3O (173.06): Calc. C 62.40 H 4.07 N 24.26; found: C 62.40 H 4.11 N 23.94. 1H NMR (400 MHz, d6-DMSO): delta (ppm) 9.439 (s, 1H, H5), 8.237 (dd, J1-2 = 8 Hz, J1-3 = 2 Hz, 1H, H1), 8.194 (dd, J4-3 = 8 Hz, J4-2 = 0.8 Hz, 1H, H4), 7.997 (q-br, J2/3-3/2/1/4 = 10 Hz, 2H, H2/3).

1865-11-8, The synthetic route of 1865-11-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1865-11-8,Methyl quinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: In a round bottom flask, the previously prepared methyl ester 2 (2 g, 10.6 mmol) was stirred in ethanol (50 mL) in the presence of cesium carbonate (0.3 g, 0.92 mmol) at ambient temperature. The progress of the reaction was followed by GC chromatography. At the end of the transesterification, the reaction mixture was evaporated to dryness and the product was extracted with dichloromethane (425 mL). The combined organic layers were then dried over MgSO4 and, after filtration, evaporated to dryness. The ethyl ester 3 was obtained as beige powder. Yield: 67percent., 1865-11-8

As the paragraph descriping shows that 1865-11-8 is playing an increasingly important role.

Reference£º
Article; Maj, Anna M.; Heyte, Svetlana; Araque, Marcia; Dumeignil, Franck; Paul, Sebastien; Suisse, Isabelle; Agbossou-Niedercorn, Francine; Tetrahedron; vol. 72; 10; (2016); p. 1375 – 1380;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1865-11-8,Methyl quinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

Methanolic ammonia (10 ml, 7N) was added to a compound methyl quinoxaiine-2-carhoxylate (1.1 g, 5.85 rnmol) at 0 ¡ãC and the reaction mixture was allowed to stir at room temperature for overnight. The reaction mixture was concentrated under reduced pressure and the crude material was purified by column chromatography on silica gel using Ethyl acetate/ilexane as an eluent to give the desired product quinoxaline-2-carboxamide (0.98 g, 566 mmoi, 97 percent ) as a solid.

1865-11-8, The synthetic route of 1865-11-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PI INDUSTRIES LTD.; SAXENA, Rohit; PANMAND, Deepak Shankar; JENA, Lalit Kumar; SRIVASTAVA, Khushboo; RAJU, Jella Rama; MANJUNATHA, Sulur G; SAMANTA, Jatin; GARG, Ruchi; AUTKAR, Santosh Shridhar; VENKATESHA, Hagalavadi M; GADAKH, Ramdas Balu; KLAUSENER, Alexander G. M.; POSCHARNY, Konstantin; (219 pag.)WO2018/116072; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a round bottom flask, the previously prepared methyl ester 2 (2 g, 10.6 mmol) was stirred in ethanol (50 mL) in the presence of cesium carbonate (0.3 g, 0.92 mmol) at ambient temperature. The progress of the reaction was followed by GC chromatography. At the end of the transesterification, the reaction mixture was evaporated to dryness and the product was extracted with dichloromethane (425 mL). The combined organic layers were then dried over MgSO4 and, after filtration, evaporated to dryness. The ethyl ester 3 was obtained as beige powder. Yield: 67percent.

1865-11-8, 1865-11-8 Methyl quinoxaline-2-carboxylate 478049, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Maj, Anna M.; Heyte, Svetlana; Araque, Marcia; Dumeignil, Franck; Paul, Sebastien; Suisse, Isabelle; Agbossou-Niedercorn, Francine; Tetrahedron; vol. 72; 10; (2016); p. 1375 – 1380;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[1500] a solution of compound 356a (2.5 g, 13.29 mmol) in CH3COOC2H5 (60 ml) was added t-BuOK (1.94 g, 17.28 mmol). The mixture was stirred for 0.25 hour at 25¡ãc. The mixture was quenched with H2O (50 ml). The organic layer was separated and the aqueous was extracted with ea (50 ml x 3). The organic phases were combined, dried with anhydrous Na2SO4, filtered and evaporated. The residue was purified by flash chromatography (pe: ea =20/1 to 10/1) to afford compound 356b (2.45 g, 75.48percent yield) as pale yellow solid. 1H NMR (CDCl3, 400 mhz) delta 9.57 – 9.33 (m, 1h), 8.19 – 8.06 (m, 2h), 7.96 – 7.74 (m, 2h), 4.35 – 4.26 (m, 2h), 4.24 – 4.13 (m, 2h), 1.28 – 1.18 (m, 3h).

1865-11-8, As the paragraph descriping shows that 1865-11-8 is playing an increasingly important role.

Reference£º
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of methyl quinoxaline-2-carboxylate (1-a) (4.0 g, 21 mmol) in ethanol (50 mL) was added acetic acid (1.2 mL, 21 mmol) and Pd/C (10 wtpercent, 2.2 g, 21 mmol). The solution was degassed and then stirred under 5 kg pressure of hydrogen for 36 hours. The mixture was filtered through CELITE (diatomaceous earth) bed and the CELITE bed waswashed with excess methanol. The combined filtrate was concentrated under reduced pressure and the mixture was purified by column chromatography (25 ? 50percent ethyl acetate in petroleum ether) to provide the titled compound (1-b), which gave a proton NMR spectra consistent with theory a mass ion [ES+] of 193.2 for [M + H]., 1865-11-8

The synthetic route of 1865-11-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; BESHORE, Douglas, C.; WU, Wen-Lian; (45 pag.)WO2017/99969; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider