Category: 25983-14-6

Zhang, Pei-Ming published the artcileA One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst, Quality Control of 25983-14-6, the main research area is dichloroquinoxaline preparation green chem; aromatic diamine oxalic acid tandem heterocyclization silica gel catalyst.

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives I (R1 = H, H3CO, Cl, etc.; R2 = H, F, CH3, etc.; R3 = H, CH3; R1R2 = CH=CH-CH=CH). The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamines 2-H2N-3-R3-4-R1-5-R2C6HNH2 and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines I have been obtained in good to excellent overall yields.

Journal of Heterocyclic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Quality Control of 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Knudsen, Lotte Bjerre published the artcileSmall-molecule agonists for the glucagon-like peptide 1 receptor, SDS of cas: 25983-14-6, the main research area is glucagon like peptide receptor agonist thiadiazolyl quinoxaline preparation SAR.

The peptide hormone glucagon-like peptide (GLP)-1 has important actions resulting in glucose lowering along with weight loss in patients with type 2 diabetes. As a peptide hormone, GLP-1 has to be administered by injection. Only a few small-mol. agonists to peptide hormone receptors have been described and none in the B family of the G protein coupled receptors to which the GLP-1 receptor belongs. We have discovered a series of small mols. known as ago-allosteric modulators selective for the human GLP-1 receptor. These compounds act as both allosteric activators of the receptor and independent agonists. Potency of GLP-1 was not changed by the allosteric agonists, but affinity of GLP-1 for the receptor was increased. The most potent compound identified (I) stimulates glucose-dependent insulin release from normal mouse islets but, importantly, not from GLP-1 receptor knockout mice. Also, the compound stimulates insulin release from perfused rat pancreas in a manner additive with GLP-1 itself. These compounds may lead to the identification or design of orally active GLP-1 agonists.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Glucagon receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, SDS of cas: 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Liu, Chun-He published the artcileDesign, synthesis, and biological evaluation of novel 4-alkylamino-1-hydroxymethylimidazo[1,2-a]quinoxalines as adenosine A1 receptor antagonists, HPLC of Formula: 25983-14-6, the main research area is oxoalkylamino chloroquinoxaline heterocyclization; imidazoquinoxaline preparation amine amination; aminoimidazoquinoxaline preparation adenosine receptor ligand.

A series of 4-alkylamino-1-hydroxymethylimidazo[1,2-a]quinoxalines, e.g., I, have been synthesized and evaluated for their adenosine A1 receptor inhibitory activity in the radioligand binding assays. These compounds were tested for the inhibition percent (IP) and the affinity toward A1AR (Ki) that IP were more than 90% in the nanomolar range. 4-Cyclopentylamino-7,8-dichloro-1-hydroxymethylimidazo[1,2-a]quinoxaline (I) was the most potent compound in this series, having Ki = 7 nM, which is remarkably higher than that of IRFI-165 (Ki = 48). 1-Hydroxymethyl groups of the tricyclic heteroaromatic compounds displayed the potent affinities toward A1AR.

Bioorganic & Medicinal Chemistry published new progress about Structure-activity relationship, purinergic receptor-binding. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, HPLC of Formula: 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Thompson, Andrew J. published the artcileStructure-Activity Relationships of Quinoxaline-Based 5-HT3A and 5-HT3AB Receptor-Selective Ligands, Name: 2,3,6,7-Tetrachloroquinoxaline, the main research area is quinoxaline preparation serotonin 5HT3 subtype receptor selective ligand.

Until recently, discriminating between homomeric 5-HT3A and heteromeric 5-HT3AB receptors was only possible with ligands that bind in the receptor pore. This study describes the first series of ligands that can discriminate between these receptor types at the level of the orthosteric binding site. During a recent fragment screen, 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline (VUF10166) was identified as a ligand that displays an 83-fold difference in [3H]granisetron binding affinity between 5-HT3A and 5-HT3AB receptors. Fragment hit exploration, initiated from VUF10166 and 3-(4-methylpiperazin-1-yl)quinoxalin-2-ol, resulted in a series of compounds with higher affinity at either 5-HT3A or 5-HT3AB receptors. These ligands reveal that a single atom is sufficient to change the selectivity profile of a compound At the extremes of the new compounds were 2-amino-3-(4-methylpiperazin-1-yl)quinoxaline (I), which showed 11-fold selectivity for the 5-HT3A receptor, and 2-(4-methylpiperazin-1-yl)quinoxaline, which showed an 8.3-fold selectivity for the 5-HT3AB receptor. These compounds represent novel mol. tools for studying 5-HT3 receptor subtypes and could help elucidate their physiol. roles.

ChemMedChem published new progress about 5-HT3 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (5-HT3AB). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Name: 2,3,6,7-Tetrachloroquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Bunz, Uwe H. F. published the artcileThe Palladium Way to N-Heteroacenes, Application In Synthesis of 25983-14-6, the main research area is heteroacene preparation palladium catalyst; review heteroacene acene preparation; N-heterocycles; acenes; electron transport materials; homogeneous catalysis; palladium.

A review with new data. Novel synthetic methodologies allow increasingly efficient access to known organic materials, as well as the preparation of otherwise inaccessible species. Pd-catalyzed coupling of aromatic dihalides to ortho-diaminoarenes furnishes embedded stable N,N’-dihydropyrazines expediently and in often excellent yields. The embedded N,N’-dihydropyrazines can then be oxidized by MnO2 to give substituted azatetracenes, azapentacenes, azahexacenes, and azaheptacenes, which are soluble, processable, and stable. This powerful Pd-catalyzed methodol. allows the preparation of azaacenes, including diaza-, tetraaza- and hexaazaacenes. In combination with ahsuitable Pd precursor, Buchwald-type biarylphosphines have been shown to give excellent results. Activated dihalides such as 2,3-dihaloquinoxalines are coupled easily under simplified conditions, whereas 2,3-dibromoacenes require more stringent conditions and advanced catalyst precursors. Pd catalysts effect the assembly of azaacenes with otherwise difficult to obtain substitution patterns. High yields and flexibility make this method most attractive.

Chemistry – A European Journal published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl dihalides). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Application In Synthesis of 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Teng, Min published the artcileSmall molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor, Formula: C8H2Cl4N2, the main research area is dichloroquinoxaline derivative preparation structure glucagon peptide hGLP1 receptor modulator.

Following the previous publication describing the biol. profiles, the authors herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small mol. agonists for the hGLP-1 receptor.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Formula: C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Isoda, Kyosuke published the artcileDipole-Driven Self-Organization of Liquid-Crystalline N-Heteroacene Derivatives Showing Redox-Properties, Product Details of C8H2Cl4N2, the main research area is dichloro trimethyldodecyloxytetraazanaphthacene preparation liquid crystal phase transition redox.

An introduction of halogen atoms to liquid-crystalline (LC) TANC derivatives to tune their electronic characters as well as the charge polarization on π-conjugated N-heteroacene framework was reported. The electroneg. Cl atoms can improve the electron-accepting property of LC TANC. Also, the induced charge polarization due to the substitution of Cl atoms generated an intrinsic dipole moment on π-conjugated N-heteroacene framework, which was able to serve as a driving force for stabilizing self-organization of N-heteroacene mols. in thin films.

ChemistrySelect published new progress about Dipole moment. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Product Details of C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lindner, Benjamin D. published the artcileSynthesis and Optical Properties of Diaza- and Tetraazatetracenes, Formula: C8H2Cl4N2, the main research area is diazatetracene tetraazatetracene preparation optical property.

A series of functionalized diaza- and tetraazatetracenes was synthesized, either by condensation of an aromatic diamine with an ortho-quinone/diethyloxalate followed by chlorination with POCl3 to give diazatetracenes or by palladium-catalyzed coupling of a phenylenediamine with various 2,3-dichloroquinoxalines to give tetraazatetracenes (after oxidation with MnO2). Representative examples included halogenated and nitrated derivatives The optical properties of these azatetracenes were discussed with respect to their mol. structures and substitution patterns. The diazatetracenes and tetraazatetracenes formed two different groups that had significantly different electronic structures and properties. Furthermore, 1,2,3,4-tetrafluoro-6,11-bis((triisopropylsilyl)ethynyl)benzo[b]phenazine was synthesized, which is the first reported fluorinated diazatetracene. Single-crystal X-ray anal. of this compound is reported.

Chemistry – A European Journal published new progress about Aryl fluorides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Formula: C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider