Category: 879-65-2

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Quinoxalinecarboxylic acid (0801-134) (1.0 g, 5.7 mmol, 1.0 eq.)Dissolved in 20 ml of methanol,Add thionyl chloride (1.25 mL, 17.2 mmol, 3.0 equivalents),Heat reflux for 3 hours.Cooled to room temperature, concentrated to dryness under reduced pressure, extracted with ethyl acetate, washed with water, liquid-separated, dried over anhydrous sodium sulfate, filtered concentrated, and concentrated under reduced pressure.After silica gel column chromatography (eluent: eluent: petroleum ether: ethyl acetate = 5:1),The product was obtained as a pale yellow solid, methyl 2-quinoxalinecarboxylate (1.01 g, yield: 93.5percent)., 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, j. Quinoxaline-2-carboxylic Acid {(S)-3-methyl-1-[3-hydroxy-1-(1-oxy-pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}amide To a solution of the compound of Example 1i (320 mg, 0.73 mmol) in CH2Cl2 was added triethylamine (0.15 mL, 1.09 mmol), EDC (140 mg, 0.73 mmol), HOBt (99 mg, 0.73 mmol) and quinoxaline-2-carboxylic acid (127 mg, 0.73 mmol). The reaction was stirred until complete by TLC analysis. Workup and column chromatography of the residue gave the title compound: MS(EI) 556 (M+).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; SmithKline Beecham Corporation; US6583137; (2003); B1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

Thionyl chloride (1 mL) was added to a solution of 2-quinoxalinecarboxylic acid (125 mg, 0.718 mmol) in methanol (20 mL). The resulting solution was stirred for 3 hours and evaporated to dryness under reduced pressure. The resulting off-white solid was collected (115 mg, 85percent). 1H NMR (400 MHz, CDCl3): delta (ppm) 9.567 (s, 1H, H5), 8.342 (dd, J1-2 = 8 Hz, J1-3 2 Hz, 1H, H1), 8.284 (dd, J4-3 = 8Hz, J4-2 = 0.8 Hz, 1H, H4), 7.938 (q-br, J2/3-3/2/1/4 = 8.4 Hz 2H, H2/3).

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
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879-65-2,879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 67QUINOXALINE-2-CARBOXYLIC ACID [(R)-1-(2-FLUORO-4-METHANESULFONYLAMINO-5-METHYLPHENYL)ETHYL]AMIDE To a stirred solution of quinoxaline-2-carboxylic acid (26 mg, 0.15 mmol), N-[4-((R)-1-aminoethyl)-5-fluoro-2-methylphenyl]methanesulfonamide hydrochloride (35 mg, 0.12 mmol), and N,N,N’,N’-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (56 mg, 0.15 mmol) in N,N-dimethylformamide (0.5 mL) was added N,N-diisopropylethylamine (80 mg, 0.6 mmol). A catalytic amount of DMAP was added, and the reaction was stirred at room temperature for 16 hours. The reaction mixture was concentrated down to a solid. The crude product was suspended in MeOH and filtered, and the filtrate purified by HPLC to give the title compound (25.0 mg, 49%) as an off-white solid. m/z=403.1 (M+1), r.t. 2.83 min. 1H NMR (400 MHz; d6-DMSO) delta 9.43 (1H, s), 9.39 (1H, d), 8.30-8.26 (1H, m), 8.22-8.18 (1H, m), 8.03-7.97 (2H, m), 7.45 (1H, d), 7.11 (1H, d), 5.49-5.39 (1H, m), 3.02 (3H, s), 2.24 (3H, s), 1.57 (3H, d).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; RENOVIS, INC.; US2012/88746; (2012); A1;,
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879-65-2,879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[1499] to a solution of quinoxaline-2-carboxylic acid (6 g, 34.45 mmol) in MeOH (80 ml) was added con. H2SO4 (675.8 mg, 6.89 mmol) dropwise, then the mixture was stirred at 65 ¡ãC for 10 hours. After cooling to room temperature, the mixture was neutralized with a sat. NaHCO3 and extracted with DCM (60 ml x 3). The organic phases were combined, dried with anhydrous Na2SO4, and evaporated to afford compound 356a (5.80 g, yield: 89.47percent) as a brown solid. The crude product was used directly in the next step without further purification. 1H NMR (CDCl3, 400 mhz) delta 9.56 (s, 1h), 8.31 (d, j = 7.6 hz, 1h), 8.20 (d, j = 8.0 hz, 1h), 7.97 – 7.84 (m, 2h), 4.13 (s, 3h).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, General procedure: The mixture of ethyl 3,4-diaminobenzoate 19 (1 eq., 7.34 mmol) and appropriate benzoic acid (1 eq., 7.34 mmol) was put under argon atmosphere and 15 mL of POCl3 were added. The whole was heated at reflux for 3 h. The mixture was cooled to room temperature, poured on ice and neutralized with 6 M NaOH (80 mL), then brought to pH ca. 9 by addition of 20 g of solid NaHCO3. 100 mL of CHCl3 were added and phases were separated. Aqueous phase was extracted with CHCl3 (2¡Á50 mL). Combined organic phases were purified by chromatography on silica gel (CHCl3/MeOH, gradient 0-5 %).

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Moszczy?ski-P?tkowski, Rafa?; Majer, Jakub; Borkowska, Ma?gorzata; Bojarski, ?ukasz; Janowska, Sylwia; Mat?oka, Miko?aj; Stefaniak, Filip; Smuga, Damian; Bazyd?o, Katarzyna; Dubiel, Krzysztof; Wieczorek, Maciej; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 96 – 116;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The tail group containing monomer, dimer ortrimer (0.266 mmol) was dissolved in methanol (25 mL), to which Pd/C-10% (60mg) was added at 0oC under nitrogen with stirring. The reactionmixture was hydrogenated at room temperature and atmospheric pressure for 4 h.The catalyst was removed over Kieselguhr and the solvent was removed underreduced pressure to give the amine, which was dissolved in DMF (1 mL, dry). Theappropriate head group carboxylic acid (0.266 mmol) was dissolved in DMF (1 mL,dry) to which HBTU (260 mg, 0.685 mmol) and triethylamine (50 muL) were added tothe reaction mixture at room temperature with stirring and the reaction mixturewas left standing at room temperature overnight. The product was purified byHPLC (no work up required). Fractions containing the product were collected andfreeze dried to give the required product., 879-65-2

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Article; Scott, Fraser J.; Puig-Sellart, Mireia; Khalaf, Abedawn I.; Henderson, Catherine J.; Westrop, Gareth; Watson, David G.; Carter, Katharine; Grant, M. Helen; Suckling, Colin J.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3478 – 3486;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, EXAMPLE 53; 2-[fOuinoxaline-2-carbonyl)-aminol-indan-2-carboxylic acid ethyl ester (53):To a solution of quinoxaline-5-carboxylic acid (400mg, 2.3mmol), 2-amino-indan-2- carboxylic acid ethyl ester (471mg, 2.3mmol), HATU (1.3g, 3.45mmol) in anhydrous DMF (15mL) is added DIPEA (570muL, 3.45mmol). The resulting solution is stirred at RT overnight.75 After the removal of DMF in vacuo, the residue is dissolved in EtOAc (5OmL) and washed with water (I x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (115g silica gel, gradient elution: 5-40% EtOAc in heptane) to give a pure product (56) as an orange solid (605mg, 73%).1H NMR (CDCl3, 300MHz): delta 1.26(t, 3H), 3.55(d, 2H), 3.84(d, 2H), 4.28(q, 2H), 7.21-7.29(m, 4H), 7.79-7.89(m, 2H), 8.08-8.18(m, 2H), 8.46(s, IH), 9.64(s, IH) LC/MS (ES+) m/z = 361.12

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; WO2008/151211; (2008); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

0.6 g Iridium (III) chloride hydrate (2 mmol), 0.79 g 5-methyl-5H-benzo[c][1,5]naphthyridin-6-one (4.4 mmol), 24 mL 2-ethoxy ethanol, and 7 mL water were added and reacted for 24 hr under nitrogen. After cooling, filtration, and washing by small amount of methanol, a chlorine-bridged dimer complex was obtained. The complex, 1.06 g sodium carbonate (Na2CO3) (10 mmol), 25 mL 2-ethoxyanol, and 0.7 g quinoxaline-2-carboxylic acid (4 mmol) were then mixed and reacted for 9 hr under nitrogen. After cooling, solid was precipitated and washed by small amount of water. After purification by silicon-gel column, 0.63 g yellow solid was obtained, with a yield of 40%.1H NMR (CDCl3, 400 MHz) spectrum data9.85 (s, 1 H), 8.58 (d, J=5.5 Hz, 1 H), 8.20 (d, J=8.4 Hz, 1 H), 7.93-7.75 (m, 4 H), 7.68 (d, J=8.5 Hz, 1 H), 7.64 (d, J=8.5 Hz, 1 H), 7.47-7.43 (m, 2 H), 7.31-7.15 (m, 3 H), 7.05 (t, J=7.6 Hz, 1 H), 6.76 (d, J=7.4 Hz, 1 H), 6.22 (d, J=7.4 Hz, 1 H), 3.80 (s, 3 H), 3.77 (s, 3 H)., 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE; US2008/214818; (2008); A1;,
Quinoxaline – Wikipedia
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879-65-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (32 mg, 0.101 mmol) obtained in Example 1, (3), quinoxaline-2-carboxylic acid (35 mg, 0.202 mmol), and O-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (42 mg, 0.111 mmol) were dissolved in DMF (2.0 mL), then the solution was added with triethylamine (20 mg, 0.202 mmol), and the mixture was stirred over night. The reaction mixture was treated in a conventional manner to obtain the title compound (10 mg, yield 21%) as yellow crystals. 1H NMR (CDCl3, 400MHz) delta: 3.63 (2H, s), 7.07 (1H, d, J=9Hz), 7.33 (2H, d, J=9Hz), 7.62 (2H, d, J=8Hz), 7.71 (1H, t, J=8Hz), 7.8-8.0 (5H, m), 8.09 (1H, d, J=8Hz), 8.1-8.3 (2H, m), 8.50 (1H, s), 9.75 (1H, s), 9.91 (1H, s)

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Nippon Chemiphar Co., Ltd.; USHIODA, Masatoshi; KOBAYASHI, Kunio; SAITO, Daisuke; SAKUMA, Shogo; IMAI, Toshiyasu; INOUE, Kazuhide; EP2803662; (2014); A1;,
Quinoxaline – Wikipedia
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