Tag: 200-300

Piras, Sandra et al. published their research in Farmaco in 2002 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate

Quinoxaline chemistry. Part 14. 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-l-glutamates as analogues-homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity was written by Piras, Sandra;Loriga, Mario;Paglietti, Giuseppe. And the article was included in Farmaco in 2002.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate This article mentions the following:

Among a new series of 26 4-(3-substituted-2-quinoxalylamino)phenylacetates and 4-(3-substituted-2-quinoxalylamino)phenylacetyl-l-glutamates, eight were selected at NCI for evaluation of their in vitro anticancer activity. The results obtained in comparison with the corresponding nor-compounds series seem to indicate that this type of homologation is not helpful. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Fernandes, P. S. et al. published their research in Journal of the Indian Chemical Society in 1986 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Application of 49679-45-0

Synthesis and biological activity of heterocyclic derivatives derived from ethyl-2-hydroxyquinoxaline-3-carboxylate was written by Fernandes, P. S.;Sonar, T. M.. And the article was included in Journal of the Indian Chemical Society in 1986.Application of 49679-45-0 This article mentions the following:

The heterocyclic derivatives of morpholinoquinoxaine I (R = Ph, 4-MeOC6H4, 4-ClC4H4; X = O, S) and II were prepared from Et 2-chloroquinoxaline-3-carboxylate in 4 steps, and were tested for their antibacterial activity. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Application of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Piras, Sandra et al. published their research in Farmaco in 2004 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Synthetic Route of C11H9ClN2O2

Quinoxaline chemistry. Part XVII. Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-{[4-(substituted 2-quinoxalinyloxy) phenyl] acetyl} glutamates analogs of methotrexate: synthesis and evaluation of in vitro anticancer activity was written by Piras, Sandra;Loriga, Mario;Paglietti, Giuseppe. And the article was included in Farmaco in 2004.Synthetic Route of C11H9ClN2O2 This article mentions the following:

Fourteen out of 21 quinoxaline derivatives described in the present paper were selected at NCI for evaluation of their in vitro anticancer activity. Preliminary screening showed that some derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 M concentrations Interesting selectivities were also recorded between 10-8 and 10-6 M for the compounds 9 and 13. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Synthetic Route of C11H9ClN2O2).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Synthetic Route of C11H9ClN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Mahesh, R. et al. published their research in Journal of Young Pharmacists in 2012 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Related Products of 49679-45-0

Antidepressant potential of 5-HT3 receptor antagonist, N-n- propyl-3-ethoxyquinoxaline-2-carboxamide (6n) was written by Mahesh, R.;Bhatt, S.;Devadoss, T.;Jindal, A. K.;Gautam, B. K.;Pandey, D. K.. And the article was included in Journal of Young Pharmacists in 2012.Related Products of 49679-45-0 This article mentions the following:

The present study was designed to evaluate the antidepressant potential of 5-HT3 receptor antagonist N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n). The compound “6n” with optimum log P and pA2 value identified from a series of compounds synthesized in our laboratory was subjected to forced Swim Test (FST) (1, 2, and 4 mg/kg, i.p) and Tail Suspension Test (TST) (1, 2, and 4 mg/kg, i.p.). The compound “6n” significantly reduced the duration of immobility in mice without affecting the baseline locomotion. Moreover, “6n” (2 mg/kg, i.p.) potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and “6n” at tested dose (1 and 2 mg/kg, i.p.) reversed the reserpine-induced hypothermia in rats. In interaction studies of “6n” with various standard drugs/ligands using FST, “6n” (1 mg/kg, i.p.) potentiated the antidepressant effect of venlafaxine (4 and 8 mg/kg, i.p.) and fluoxetine (10 and 20 mg/kg, i.p.). Addnl., “6n” (1 and 2 mg/kg, i.p.) influenced the effect of harmane (5 mg/kg, i.p.) as well as reversed the effect of parthenolide (1 mg/kg, i.p.) by reducing the duration of immobility in FST. Furthermore, “6n” (1 mg/kg/, i.p.) potentiated the effect of bupropion (10 and 20 mg/kg, i.p.) in TST. Chronic “6n” (1 and 2 mg/kg, i.p.) treatment attenuated the behavioral abnormalities in olfactory bulbectomized rats. In conclusion, these various findings reiterated the antidepressant-like effects of “6n” in behavioral models of depression. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Related Products of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Related Products of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Fernandes, P. S. et al. published their research in Journal of the Indian Chemical Society in 1986 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Application of 49679-45-0

Synthesis and biological activity of heterocyclic derivatives derived from ethyl-2-hydroxyquinoxaline-3-carboxylate was written by Fernandes, P. S.;Sonar, T. M.. And the article was included in Journal of the Indian Chemical Society in 1986.Application of 49679-45-0 This article mentions the following:

The heterocyclic derivatives of morpholinoquinoxaine I (R = Ph, 4-MeOC6H4, 4-ClC4H4; X = O, S) and II were prepared from Et 2-chloroquinoxaline-3-carboxylate in 4 steps, and were tested for their antibacterial activity. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Application of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Piras, Sandra et al. published their research in Farmaco in 2002 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate

Quinoxaline chemistry. Part 14. 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-l-glutamates as analogues-homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity was written by Piras, Sandra;Loriga, Mario;Paglietti, Giuseppe. And the article was included in Farmaco in 2002.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate This article mentions the following:

Among a new series of 26 4-(3-substituted-2-quinoxalylamino)phenylacetates and 4-(3-substituted-2-quinoxalylamino)phenylacetyl-l-glutamates, eight were selected at NCI for evaluation of their in vitro anticancer activity. The results obtained in comparison with the corresponding nor-compounds series seem to indicate that this type of homologation is not helpful. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Li, Xuan et al. published their research in Tetrahedron Letters in 2022 | CAS: 1910-90-3

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Electric Literature of C8H5BrN2O2

Metal & Surfactant-Free oxidation of Quinoxalin-2(1H)-ones: Access to Quinoxaline-2,3-diones was written by Li, Xuan;Zang, Jiawang;Wang, Shoucai;Kang, Chen;Xu, Jiawei;Jiang, Guangbin;Ji, Fanghua. And the article was included in Tetrahedron Letters in 2022.Electric Literature of C8H5BrN2O2 This article mentions the following:

An efficient and direct metal & surfactant-free surfactant-free oxidation of quinoxalin-2(1H)-ones for the construction of 1,4-dihydroquinoxaline-2,3-diones I [R = Me, Et, Bn, etc.; R1 = H, 7-NO2, 6-OMe, etc.] was developed. A range of oxidative products are obtained with satisfactory yields (up to 99%). This practical method featured transition metal free, surfactant free, chromatog. free, mild reaction conditions, good functional group tolerance and easy scale-up synthesis. Furthermore, it provided a convenient approach for the synthesis of one kind of known inhibitor for α-glucosidase. This mechanistic study showed that this transformation was not a radical process. In the experiment, the researchers used many compounds, for example, 6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3Electric Literature of C8H5BrN2O2).

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Electric Literature of C8H5BrN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Hamby, James M. et al. published their research in Journal of Heterocyclic Chemistry in 1987 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Related Products of 49679-45-0

A comparison of nucleophilic reactions of 3-benzenesulfonyloxyalloxazine and its 1-methyl analog was written by Hamby, James M.;Bauer, Ludwig. And the article was included in Journal of Heterocyclic Chemistry in 1987.Related Products of 49679-45-0 This article mentions the following:

Reactions of 3-benzenesulfonyloxyalloxazines I (R = H, Me) with a number of nucleophilic reagents are reported. Relatively small nucleophiles, such as HO–, MeOH, EtOH, MeNH2, N2H4, and HONH2, converted I (R = H) to 4-carboxy-s-triazolo[4,3-a]quinoxalin-1(2H)-ones and the corresponding esters ar amides. As the size of the amine increased from MeNH2 to EtNH2, Me2NH2, PrNH2, and Me2CHNH2, there were obtained 4-(carboxamido)-s-triazolo[4,3-a]quinoxalin-1(2H)-ones, (1-carboxamido)imidazolo[4,5-b]quinoxalines, and 2,3-bis(ureido)quinoxalines. NaH or KCN in hot DMF degraded I (R = H) to imidazolo[4,5-b]quinoxaline. However, MeSH and PhCH2SH ions attacked the sulfonate group of I (R = H) to form 3-hydroxyalloxazine. I (R = Me) reacted with MeOH, EtOH, PrOH, and to some degree Me2CHOH, in the presence of Et3N to furnish anhydro-1-hydroxy-3-methyl-4-(alkoxycarbonyl)-s-triazolo[4,3-a]quinoxalinium hydroxides. However, NaOMe in MeOH converted I (R = Me) to a mixture of anhydro-1-hydroxy-3-methyl-s-triazolo[4,3-a]quinoxalinium hydroxide (II) and 1-methyl-3-hydroxyflavazole. A saturated aqueous solution of Et3N transformed I (R = Me) to II, apparently via the corresponding unstable 4-carboxylic acid. Reactions of I (R = Me) with a number of aliphatic amines yielded either amides based on the above mesoionic system or on the 3-carboxamido-2-quinoxalyl semicarbazide structure. Reaction of I (R = Me) with KCN furnished 1-methylimidazolo[4,5-b]quinoxaline. Mechanisms to explain all of the degradations are advanced. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Related Products of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Related Products of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Mahesh, Radhakrishnan et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Reference of 49679-45-0

Discovery of new anti-depressants from structurally novel 5-HT3 receptor antagonists: Design, synthesis and pharmacological evaluation of 3-ethoxyquinoxalin-2-carboxamides was written by Mahesh, Radhakrishnan;Devadoss, Thangaraj;Pandey, Dilip Kumar;Bhatt, Shvetank. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Reference of 49679-45-0 This article mentions the following:

A novel series of 3-ethoxyquinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT3 receptor antagonist using ligand-based approach. The desired carboxamides were synthesized from the key intermediate, 3-ethoxyquinoxalin-2-carboxylic acid by coupling with appropriate amines in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole. The 5-HT3 receptor antagonism was evaluated in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, which was expressed in the form of pA 2 values. (3-Ethoxyquinoxalin-2-yl)(4-methylpiperazin-1-yl)methanone was found to be the most active compound, which expressed a pA 2 value of 7.7. In forced swim test, the compounds with higher pA 2 value exhibited good anti-depressant-like activity and compounds with lower pA 2 value failed to show activity as compared to the vehicle-treated group. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Reference of 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Reference of 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Mahesh, Radhakrishnan et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 2012 | CAS: 49679-45-0

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Formula: C11H9ClN2O2

Ligand-Based Design, Synthesis, and Pharmacological Evaluation of 3-Methoxyquinoxalin-2-carboxamides as Structurally Novel Serotonin Type-3 Receptor Antagonists was written by Mahesh, Radhakrishnan;Devadoss, Thangaraj;Dhar, Arghya Kusum;Venkatesh, Sudali Muthu;Mundra, Sourabh;Pandey, Dilip Kumar;Bhatt, Shvetank;Jindal, Ankur Kumar. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2012.Formula: C11H9ClN2O2 This article mentions the following:

Employing a ligand-based approach, 3-methoxyquinoxalin-2-carboxamides were designed as serotonin type-3 (5-HT3) receptor antagonists and synthesized from the starting material o-phenylenediamine in a sequence of reactions. The structures of the synthesized compounds were confirmed by spectral data. These carboxamides were investigated for their 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparations from guinea-pig ileum against a standard 5-HT3 agonist, 2-methyl-5-HT, and their antagonism activities are expressed as pA2 values. Some compounds exhibited antagonism greater than that of the standard 5-HT3 antagonist, ondansetron. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Formula: C11H9ClN2O2).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Formula: C11H9ClN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider